MR elastography of the abdomen: Experimental protocols

Suraj D. Serai, Meng Yin

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Application of MRE for noninvasive evaluation of renal fibrosis has great potential for noninvasive assessment in patients with chronic kidney disease (CKD). CKD leads to severe complications, which require dialysis or kidney transplant and could even result in death. CKD in native kidneys and interstitial fibrosis in allograft kidneys are the two major kidney fibrotic pathologies where MRE may be clinically useful. Both these conditions can lead to extensive morbidity, mortality, and high health care costs. Currently, biopsy is the standard method for renal fibrosis staging. This method of diagnosis is painful, invasive, limited by sampling bias, exhibits inter- and intraobserver variability, requires prolonged hospitalization, poses risk of complications and significant bleeding, and could even lead to death. MRE based methods can potentially be useful to noninvasively detect, stage, and monitor renal fibrosis, reducing the need for renal biopsy. In this chapter, we describe experimental procedure and step by step instructions to run MRE along with some illustrative applications. We also includes sections on how to perform data quality check and analysis methods. This publication is based upon work from the COST Action PARENCHIMA, a community-driven network funded by the European Cooperation in Science and Technology (COST) program of the European Union, which aims to improve the reproducibility and standardization of renal MRI biomarkers.

Original languageEnglish (US)
Title of host publicationMethods in Molecular Biology
PublisherHumana Press Inc.
Pages519-546
Number of pages28
DOIs
StatePublished - 2021

Publication series

NameMethods in Molecular Biology
Volume2216
ISSN (Print)1064-3745
ISSN (Electronic)1940-6029

Keywords

  • Chronic kidney disease (CKD)
  • Fibrosis
  • Kidney
  • MRI
  • Magnetic resonance elastography (MRE)
  • Preclinical imaging
  • Stiffness

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics

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