MR elastography of human lung parenchyma: Technical development, theoretical modeling and in vivo validation

Yogesh K. Mariappan, Kevin J. Glaser, Rolf D. Hubmayr, Armando Manduca, Richard Lorne Ehman, Kiaran Patrick McGee

Research output: Contribution to journalArticle

38 Citations (Scopus)

Abstract

Purpose: To develop a novel MR-based method for visualizing the elastic properties of human lung parenchyma in vivo and to evaluate the ability of this method to resolve differences in parenchymal stiffness at different respiration states in healthy volunteers. Materials and Methods: A spin-echo MR Elastography (MRE) pulse sequence was developed to provide both high shear wave motion sensitivity and short TE for improved visualization of lung parenchyma. The improved motion sensitivity of this approach was modeled and tested with phantom experiments. In vivo testing was then performed on 10 healthy volunteers at the respiratory states of residual volume (RV) and total lung capacity (TLC). Results: Shear wave propagation was visualized within the lungs of all volunteers and was processed to provide parenchymal shear stiffness maps for all 10 subjects. Density corrected stiffness values at TLC (1.83 ± 0.22 kPa) were higher than those at the RV (1.14 ± 0.14 kPa) with the difference being statistically significant (P < 0.0001). Conclusion: 1H-based MR elastography can noninvasively measure the shear stiffness of human lung parenchyma in vivo and can quantitate the change in shear stiffness due to respiration. The values obtained were consistent with previously reported in vitro assessments of cadaver lungs. Further work is required to increase the flexibility of the current acquisition and to investigate the clinical potential of lung MRE.

Original languageEnglish (US)
Pages (from-to)1351-1361
Number of pages11
JournalJournal of Magnetic Resonance Imaging
Volume33
Issue number6
DOIs
StatePublished - Jun 2011

Fingerprint

Elasticity Imaging Techniques
Lung
Total Lung Capacity
Residual Volume
Healthy Volunteers
Respiration
Cadaver
Volunteers

Keywords

  • lung elastography
  • lung stiffness
  • mechanical properties
  • MR elastography
  • shear stiffness

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

Cite this

MR elastography of human lung parenchyma : Technical development, theoretical modeling and in vivo validation. / Mariappan, Yogesh K.; Glaser, Kevin J.; Hubmayr, Rolf D.; Manduca, Armando; Ehman, Richard Lorne; McGee, Kiaran Patrick.

In: Journal of Magnetic Resonance Imaging, Vol. 33, No. 6, 06.2011, p. 1351-1361.

Research output: Contribution to journalArticle

@article{17a27f4c22e243019d65abcf5696ed37,
title = "MR elastography of human lung parenchyma: Technical development, theoretical modeling and in vivo validation",
abstract = "Purpose: To develop a novel MR-based method for visualizing the elastic properties of human lung parenchyma in vivo and to evaluate the ability of this method to resolve differences in parenchymal stiffness at different respiration states in healthy volunteers. Materials and Methods: A spin-echo MR Elastography (MRE) pulse sequence was developed to provide both high shear wave motion sensitivity and short TE for improved visualization of lung parenchyma. The improved motion sensitivity of this approach was modeled and tested with phantom experiments. In vivo testing was then performed on 10 healthy volunteers at the respiratory states of residual volume (RV) and total lung capacity (TLC). Results: Shear wave propagation was visualized within the lungs of all volunteers and was processed to provide parenchymal shear stiffness maps for all 10 subjects. Density corrected stiffness values at TLC (1.83 ± 0.22 kPa) were higher than those at the RV (1.14 ± 0.14 kPa) with the difference being statistically significant (P < 0.0001). Conclusion: 1H-based MR elastography can noninvasively measure the shear stiffness of human lung parenchyma in vivo and can quantitate the change in shear stiffness due to respiration. The values obtained were consistent with previously reported in vitro assessments of cadaver lungs. Further work is required to increase the flexibility of the current acquisition and to investigate the clinical potential of lung MRE.",
keywords = "lung elastography, lung stiffness, mechanical properties, MR elastography, shear stiffness",
author = "Mariappan, {Yogesh K.} and Glaser, {Kevin J.} and Hubmayr, {Rolf D.} and Armando Manduca and Ehman, {Richard Lorne} and McGee, {Kiaran Patrick}",
year = "2011",
month = "6",
doi = "10.1002/jmri.22550",
language = "English (US)",
volume = "33",
pages = "1351--1361",
journal = "Journal of Magnetic Resonance Imaging",
issn = "1053-1807",
publisher = "John Wiley and Sons Inc.",
number = "6",

}

TY - JOUR

T1 - MR elastography of human lung parenchyma

T2 - Technical development, theoretical modeling and in vivo validation

AU - Mariappan, Yogesh K.

AU - Glaser, Kevin J.

AU - Hubmayr, Rolf D.

AU - Manduca, Armando

AU - Ehman, Richard Lorne

AU - McGee, Kiaran Patrick

PY - 2011/6

Y1 - 2011/6

N2 - Purpose: To develop a novel MR-based method for visualizing the elastic properties of human lung parenchyma in vivo and to evaluate the ability of this method to resolve differences in parenchymal stiffness at different respiration states in healthy volunteers. Materials and Methods: A spin-echo MR Elastography (MRE) pulse sequence was developed to provide both high shear wave motion sensitivity and short TE for improved visualization of lung parenchyma. The improved motion sensitivity of this approach was modeled and tested with phantom experiments. In vivo testing was then performed on 10 healthy volunteers at the respiratory states of residual volume (RV) and total lung capacity (TLC). Results: Shear wave propagation was visualized within the lungs of all volunteers and was processed to provide parenchymal shear stiffness maps for all 10 subjects. Density corrected stiffness values at TLC (1.83 ± 0.22 kPa) were higher than those at the RV (1.14 ± 0.14 kPa) with the difference being statistically significant (P < 0.0001). Conclusion: 1H-based MR elastography can noninvasively measure the shear stiffness of human lung parenchyma in vivo and can quantitate the change in shear stiffness due to respiration. The values obtained were consistent with previously reported in vitro assessments of cadaver lungs. Further work is required to increase the flexibility of the current acquisition and to investigate the clinical potential of lung MRE.

AB - Purpose: To develop a novel MR-based method for visualizing the elastic properties of human lung parenchyma in vivo and to evaluate the ability of this method to resolve differences in parenchymal stiffness at different respiration states in healthy volunteers. Materials and Methods: A spin-echo MR Elastography (MRE) pulse sequence was developed to provide both high shear wave motion sensitivity and short TE for improved visualization of lung parenchyma. The improved motion sensitivity of this approach was modeled and tested with phantom experiments. In vivo testing was then performed on 10 healthy volunteers at the respiratory states of residual volume (RV) and total lung capacity (TLC). Results: Shear wave propagation was visualized within the lungs of all volunteers and was processed to provide parenchymal shear stiffness maps for all 10 subjects. Density corrected stiffness values at TLC (1.83 ± 0.22 kPa) were higher than those at the RV (1.14 ± 0.14 kPa) with the difference being statistically significant (P < 0.0001). Conclusion: 1H-based MR elastography can noninvasively measure the shear stiffness of human lung parenchyma in vivo and can quantitate the change in shear stiffness due to respiration. The values obtained were consistent with previously reported in vitro assessments of cadaver lungs. Further work is required to increase the flexibility of the current acquisition and to investigate the clinical potential of lung MRE.

KW - lung elastography

KW - lung stiffness

KW - mechanical properties

KW - MR elastography

KW - shear stiffness

UR - http://www.scopus.com/inward/record.url?scp=79958255153&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=79958255153&partnerID=8YFLogxK

U2 - 10.1002/jmri.22550

DO - 10.1002/jmri.22550

M3 - Article

C2 - 21591003

AN - SCOPUS:79958255153

VL - 33

SP - 1351

EP - 1361

JO - Journal of Magnetic Resonance Imaging

JF - Journal of Magnetic Resonance Imaging

SN - 1053-1807

IS - 6

ER -