MR elastography of breast cancer: Preliminary results

Alexia L. McKnight, Jennifer L. Kugel, Phillip J. Rossman, Armando Manduca, Lynn C. Hartmann, Richard Lorne Ehman

Research output: Contribution to journalArticle

269 Citations (Scopus)

Abstract

OBJECTIVE. Motivated by the long-recognized value of palpation in detecting breast cancer, we tested the feasibility of a technique for quantitatively evaluating the mechanical properties of breast tissues on the basis of direct MR imaging visualization of acoustic waves. SUBJECTS AND METHODS. The prototypic elasticity imaging technique consists of a device for generating acoustic shear waves in tissue, an MR imaging-based method for imaging the propagation of these waves, and an algorithm for processing the wave images to generate quantitative images depicting tissue stiffness. After tests with tissue-simulating phantom materials and breast cancer specimens, we used the prototypic breast MR elastography technique to image six healthy women and six patients with known breast cancer. RESULTS. Acoustic shear waves were clearly visualized in phantoms, breast cancer specimens, healthy volunteers, and patients with breast cancer. The elastograms of the tumor specimens showed focal areas of high shear stiffness. MR elastograms of healthy volunteers revealed moderately heterogeneous mechanical properties, with the shear stiffness of fibroglandular tissue measuring slightly higher than that of adipose tissue. The elastograms of patients with breast cancer showed focal areas of high shear stiffness corresponding to the locations of the known tumors. The mean shear stiffness of breast carcinoma was 418% higher than the mean value of surrounding breast tissues. CONCLUSION. The results confirm the hypothesis that the prototypic breast MR elastographic technique can quantitatively depict the elastic properties of breast tissues in vivo and reveal high shear elasticity in known breast tumors. Further research is needed to evaluate the potential applications of MR elastography, such as detecting breast carcinoma and characterizing suspicious breast lesions.

Original languageEnglish (US)
Pages (from-to)1411-1417
Number of pages7
JournalAmerican Journal of Roentgenology
Volume178
Issue number6
StatePublished - 2002

Fingerprint

Elasticity Imaging Techniques
Breast Neoplasms
Breast
Healthy Volunteers
Palpation
Elasticity
Adipose Tissue
Neoplasms
Equipment and Supplies

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology

Cite this

McKnight, A. L., Kugel, J. L., Rossman, P. J., Manduca, A., Hartmann, L. C., & Ehman, R. L. (2002). MR elastography of breast cancer: Preliminary results. American Journal of Roentgenology, 178(6), 1411-1417.

MR elastography of breast cancer : Preliminary results. / McKnight, Alexia L.; Kugel, Jennifer L.; Rossman, Phillip J.; Manduca, Armando; Hartmann, Lynn C.; Ehman, Richard Lorne.

In: American Journal of Roentgenology, Vol. 178, No. 6, 2002, p. 1411-1417.

Research output: Contribution to journalArticle

McKnight, AL, Kugel, JL, Rossman, PJ, Manduca, A, Hartmann, LC & Ehman, RL 2002, 'MR elastography of breast cancer: Preliminary results', American Journal of Roentgenology, vol. 178, no. 6, pp. 1411-1417.
McKnight AL, Kugel JL, Rossman PJ, Manduca A, Hartmann LC, Ehman RL. MR elastography of breast cancer: Preliminary results. American Journal of Roentgenology. 2002;178(6):1411-1417.
McKnight, Alexia L. ; Kugel, Jennifer L. ; Rossman, Phillip J. ; Manduca, Armando ; Hartmann, Lynn C. ; Ehman, Richard Lorne. / MR elastography of breast cancer : Preliminary results. In: American Journal of Roentgenology. 2002 ; Vol. 178, No. 6. pp. 1411-1417.
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