TY - JOUR
T1 - MR Elastography-Based Shear Strain Mapping for Assessment of Microvascular Invasion in Hepatocellular Carcinoma
AU - Li, Mengsi
AU - Yin, Ziying
AU - Hu, Bing
AU - Guo, Ning
AU - Zhang, Linqi
AU - Zhang, Lina
AU - Zhu, Jie
AU - Chen, Wenying
AU - Yin, Meng
AU - Chen, Jun
AU - Ehman, Richard L.
AU - Wang, Jin
N1 - Publisher Copyright:
© 2022, The Author(s), under exclusive licence to European Society of Radiology.
PY - 2022/7
Y1 - 2022/7
N2 - Objectives: To evaluate the potential of MR elastography (MRE)–based shear strain mapping to noninvasively predict the presence of microvascular invasion (MVI) in hepatocellular carcinoma (HCC). Methods: Fifty-nine histopathology-proven HCC patients with conventional 60-Hz MRE examinations (+/−MVI, n = 34/25) were enrolled retrospectively between December 2016 and October 2019, with one subgroup comprising 29/59 patients (+/−MVI, n = 16/13) who also underwent 40- and 30-Hz MRE examinations. Octahedral shear strain (OSS) maps were calculated, and the percentage of peritumoral interface length with low shear strain (i.e., a low-shear-strain length, pLSL, %) was recorded. For OSS-pLSL, differences between the MVI (+) and MVI (−) groups and diagnostic performance at different MRE frequencies were analyzed using the Mann-Whitney test and area under the receiver operating characteristic curve (AUC), respectively. Results: The peritumor OSS-pLSL was significantly higher in the MVI (+) group than in the MVI (−) group at the three frequencies (all p < 0.01). The AUC of peritumor OSS-pLSL for predicting MVI was good/excellent in all frequency groups (60-Hz: 0.73 (n = 59)/0.80 (n = 29); 40-Hz: 0.84; 30-Hz: 0.90). On further analysis of the 29 cases with all frequencies, the AUCs were not significantly different. As the frequency decreased from 60-Hz, the specificity of OSS increased at 40-Hz (53.8–61.5%) and further increased at 30-Hz (53.8–76.9%), and the sensitivity remained high at lower frequencies (100.0–93.8%) (all p > 0.05). Conclusions: MRE-based shear strain mapping is a promising technique for noninvasively predicting the presence of MVI in patients with HCC, and the most recommended frequency for OSS is 30-Hz. Key Points: • MR elastography (MRE)–based shear strain mapping has the potential to predict the presence of microvascular invasion (MVI) in hepatocellular carcinoma preoperatively. • The low interface shear strain identified at tumor–liver boundaries was highly correlated with the presence of MVI.
AB - Objectives: To evaluate the potential of MR elastography (MRE)–based shear strain mapping to noninvasively predict the presence of microvascular invasion (MVI) in hepatocellular carcinoma (HCC). Methods: Fifty-nine histopathology-proven HCC patients with conventional 60-Hz MRE examinations (+/−MVI, n = 34/25) were enrolled retrospectively between December 2016 and October 2019, with one subgroup comprising 29/59 patients (+/−MVI, n = 16/13) who also underwent 40- and 30-Hz MRE examinations. Octahedral shear strain (OSS) maps were calculated, and the percentage of peritumoral interface length with low shear strain (i.e., a low-shear-strain length, pLSL, %) was recorded. For OSS-pLSL, differences between the MVI (+) and MVI (−) groups and diagnostic performance at different MRE frequencies were analyzed using the Mann-Whitney test and area under the receiver operating characteristic curve (AUC), respectively. Results: The peritumor OSS-pLSL was significantly higher in the MVI (+) group than in the MVI (−) group at the three frequencies (all p < 0.01). The AUC of peritumor OSS-pLSL for predicting MVI was good/excellent in all frequency groups (60-Hz: 0.73 (n = 59)/0.80 (n = 29); 40-Hz: 0.84; 30-Hz: 0.90). On further analysis of the 29 cases with all frequencies, the AUCs were not significantly different. As the frequency decreased from 60-Hz, the specificity of OSS increased at 40-Hz (53.8–61.5%) and further increased at 30-Hz (53.8–76.9%), and the sensitivity remained high at lower frequencies (100.0–93.8%) (all p > 0.05). Conclusions: MRE-based shear strain mapping is a promising technique for noninvasively predicting the presence of MVI in patients with HCC, and the most recommended frequency for OSS is 30-Hz. Key Points: • MR elastography (MRE)–based shear strain mapping has the potential to predict the presence of microvascular invasion (MVI) in hepatocellular carcinoma preoperatively. • The low interface shear strain identified at tumor–liver boundaries was highly correlated with the presence of MVI.
KW - Elasticity imaging techniques
KW - Hepatocellular carcinoma
KW - Magnetic resonance
KW - Tissue adhesions
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U2 - 10.1007/s00330-022-08578-w
DO - 10.1007/s00330-022-08578-w
M3 - Article
C2 - 35147777
AN - SCOPUS:85124414007
SN - 0938-7994
VL - 32
SP - 5024
EP - 5032
JO - European radiology
JF - European radiology
IS - 7
ER -