Mouse T lymphocyte response to acetylcholine receptor determined by T cell receptor for antigen Vβ gene products recognizing Mls-1a

C. J. Krco, C. S. David, V. A. Lennon

Research output: Contribution to journalArticle

12 Scopus citations


Mice of strain B6, but not AKR/J, respond to immunization with Torpedo acetylcholine receptor (AChR) by manifesting in vitro an Ag-specific T lymphocyte proliferative response. Our analysis of (AKR x B6)F1 mice reveals that the T cell unresponsiveness of AKR/J is inherited as a dominant trait, possibly associated with expression of the Mls-1a allele. Mice derived from backcrossing (AKR x B6)F1 x B6 were selected for H-2b homozygosity and were classified as Mls-1a or Mls-1b according to the relative numbers of peripheral blood T cells that expressed the TCR Vβ6 gene product. After challenge by injection with AChR in CFA, lymph node cells from mice classified as having <2% of Vβ6+ peripheral T cells had low responsiveness to AChR, whereas mice with >7% Vβ6+ peripheral T cells had high T cell responsiveness to AChR. These results are consistent with the notion that regulation of the T cell repertoire by Mls loci may be a determinant of susceptibility to autoimmunity.

Original languageEnglish (US)
Pages (from-to)3303-3305
Number of pages3
JournalJournal of Immunology
Issue number10
StatePublished - Jan 1 1991


ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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