Mouse 5-HT(2B) receptor-mediated serotonin trophic functions

Doo Sup Choi, O. Kellermann, S. Richard, J. F. Colas, F. Bolaños-Jimenez, C. Tournois, J. M. Launay, L. Maroteaux

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

5-HT(2B) receptors, in addition to phospholipase C stimulation, are able to trigger activation of the proto-oncogene product p21(ras). During mouse embryogenesis, a peak of 5-HT(2B) receptor expression is detected at the neurulation stage; we localized the 5-HT(2B) expression in neural crest cells, heart myocardium, and somites. The requirement for functional 5-HT(2B) receptors shortly after gastrulation, is supported by culture of embryos exposed to 5-HT(2B)-high affinity antagonist such as ritanserin, which induces morphological defects in the cephalic region, heart and neural tube. Functional 5-HT(2B) receptors are also expressed during the serotonergic differentiation of the mouse F9 teratocarcinoma-derived clonal cell line 1C11. Upon 2 days of induction by cAMP, 5-HT(2B) receptors become functional, and on day 4, the appearance of 5-HT(2A) receptors coincides with the onset of active serotonin transporter by these cells. Active serotonin uptake is modulated by serotonin suggesting autoreceptor functions for 5-HT(2B) receptors.

Original languageEnglish (US)
Pages (from-to)67-73
Number of pages7
JournalAnnals of the New York Academy of Sciences
Volume861
DOIs
StatePublished - 1998
Externally publishedYes

Fingerprint

Receptor, Serotonin, 5-HT2B
Serotonin
Ritanserin
Neurulation
Proto-Oncogene Proteins p21(ras)
Teratocarcinoma
Receptor, Serotonin, 5-HT2A
Autoreceptors
Somites
Gastrulation
Serotonin Plasma Membrane Transport Proteins
Neural Tube
Neural Crest
Type C Phospholipases
Embryonic Development
Mouse
Cells
Myocardium
Embryonic Structures
Chemical activation

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Choi, D. S., Kellermann, O., Richard, S., Colas, J. F., Bolaños-Jimenez, F., Tournois, C., ... Maroteaux, L. (1998). Mouse 5-HT(2B) receptor-mediated serotonin trophic functions. Annals of the New York Academy of Sciences, 861, 67-73. https://doi.org/10.1111/j.1749-6632.1998.tb10174.x

Mouse 5-HT(2B) receptor-mediated serotonin trophic functions. / Choi, Doo Sup; Kellermann, O.; Richard, S.; Colas, J. F.; Bolaños-Jimenez, F.; Tournois, C.; Launay, J. M.; Maroteaux, L.

In: Annals of the New York Academy of Sciences, Vol. 861, 1998, p. 67-73.

Research output: Contribution to journalArticle

Choi, DS, Kellermann, O, Richard, S, Colas, JF, Bolaños-Jimenez, F, Tournois, C, Launay, JM & Maroteaux, L 1998, 'Mouse 5-HT(2B) receptor-mediated serotonin trophic functions', Annals of the New York Academy of Sciences, vol. 861, pp. 67-73. https://doi.org/10.1111/j.1749-6632.1998.tb10174.x
Choi, Doo Sup ; Kellermann, O. ; Richard, S. ; Colas, J. F. ; Bolaños-Jimenez, F. ; Tournois, C. ; Launay, J. M. ; Maroteaux, L. / Mouse 5-HT(2B) receptor-mediated serotonin trophic functions. In: Annals of the New York Academy of Sciences. 1998 ; Vol. 861. pp. 67-73.
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