TY - JOUR
T1 - Mouse 5-HT(2B) receptor-mediated serotonin trophic functions
AU - Choi, D. S.
AU - Kellermann, O.
AU - Richard, S.
AU - Colas, J. F.
AU - Bolaños-Jimenez, F.
AU - Tournois, C.
AU - Launay, J. M.
AU - Maroteaux, L.
PY - 1998
Y1 - 1998
N2 - 5-HT(2B) receptors, in addition to phospholipase C stimulation, are able to trigger activation of the proto-oncogene product p21(ras). During mouse embryogenesis, a peak of 5-HT(2B) receptor expression is detected at the neurulation stage; we localized the 5-HT(2B) expression in neural crest cells, heart myocardium, and somites. The requirement for functional 5-HT(2B) receptors shortly after gastrulation, is supported by culture of embryos exposed to 5-HT(2B)-high affinity antagonist such as ritanserin, which induces morphological defects in the cephalic region, heart and neural tube. Functional 5-HT(2B) receptors are also expressed during the serotonergic differentiation of the mouse F9 teratocarcinoma-derived clonal cell line 1C11. Upon 2 days of induction by cAMP, 5-HT(2B) receptors become functional, and on day 4, the appearance of 5-HT(2A) receptors coincides with the onset of active serotonin transporter by these cells. Active serotonin uptake is modulated by serotonin suggesting autoreceptor functions for 5-HT(2B) receptors.
AB - 5-HT(2B) receptors, in addition to phospholipase C stimulation, are able to trigger activation of the proto-oncogene product p21(ras). During mouse embryogenesis, a peak of 5-HT(2B) receptor expression is detected at the neurulation stage; we localized the 5-HT(2B) expression in neural crest cells, heart myocardium, and somites. The requirement for functional 5-HT(2B) receptors shortly after gastrulation, is supported by culture of embryos exposed to 5-HT(2B)-high affinity antagonist such as ritanserin, which induces morphological defects in the cephalic region, heart and neural tube. Functional 5-HT(2B) receptors are also expressed during the serotonergic differentiation of the mouse F9 teratocarcinoma-derived clonal cell line 1C11. Upon 2 days of induction by cAMP, 5-HT(2B) receptors become functional, and on day 4, the appearance of 5-HT(2A) receptors coincides with the onset of active serotonin transporter by these cells. Active serotonin uptake is modulated by serotonin suggesting autoreceptor functions for 5-HT(2B) receptors.
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U2 - 10.1111/j.1749-6632.1998.tb10174.x
DO - 10.1111/j.1749-6632.1998.tb10174.x
M3 - Article
C2 - 9928240
AN - SCOPUS:0032534298
SN - 0077-8923
VL - 861
SP - 67
EP - 73
JO - Annals of the New York Academy of Sciences
JF - Annals of the New York Academy of Sciences
ER -