Motor responses to food of the ileum, proximal colon, and distal colon of healthy humans

Paul Kerlin, Alan Zinsmeister, Sidney Phillips

Research output: Contribution to journalArticle

108 Citations (Scopus)

Abstract

Intraluminal pressures and motility indexes were recorded from ileum, ascending colon, rectosigmoid colon, and rectum of 6 healthy men. Three different test meals were eaten at 5-hour intervals. During fasting, migrating motor complexes were identified in the ileum. In ascending colon, irregular, isolated peaks of pressure were common; when bursts of continuous activity occurred, their predominant frequency was 6/min. Regular contractile activity occurred in distal colon at a frequency of 2.5-3.5/min, although 3 subjects also demonstrated rates of 7/min. There were both synchronous and independent contractions of the rectosigmoid and rectum, and no temporal relationship was obvious between motor activities of ascending and distal colons. When the preprandial hour contained no migrating motor complex, all meals increased the ileal motility index by 50%. The motility index of ascending and rectosigmoid colons were enhanced by solid meals, but not by meals containing amino acids. We conclude that motor patterns in the colon vary regionally, both fasting and after food. Results obtained at one site of the large intestine should not be extrapolated to others.

Original languageEnglish (US)
Pages (from-to)762-770
Number of pages9
JournalGastroenterology
Volume84
Issue number4
StatePublished - 1983

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Ascending Colon
Ileum
Meals
Colon
Migrating Myoelectric Complexes
Food
Rectum
Fasting
Pressure
Large Intestine
Motor Activity
Amino Acids

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Kerlin, P., Zinsmeister, A., & Phillips, S. (1983). Motor responses to food of the ileum, proximal colon, and distal colon of healthy humans. Gastroenterology, 84(4), 762-770.

Motor responses to food of the ileum, proximal colon, and distal colon of healthy humans. / Kerlin, Paul; Zinsmeister, Alan; Phillips, Sidney.

In: Gastroenterology, Vol. 84, No. 4, 1983, p. 762-770.

Research output: Contribution to journalArticle

Kerlin, P, Zinsmeister, A & Phillips, S 1983, 'Motor responses to food of the ileum, proximal colon, and distal colon of healthy humans', Gastroenterology, vol. 84, no. 4, pp. 762-770.
Kerlin, Paul ; Zinsmeister, Alan ; Phillips, Sidney. / Motor responses to food of the ileum, proximal colon, and distal colon of healthy humans. In: Gastroenterology. 1983 ; Vol. 84, No. 4. pp. 762-770.
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