Abstract
This study presents data on the antemortem evaluations of a cohort of individuals registered in a brain donation program. Clinical evaluation determined that many individuals were unaware they had clinical signs of Parkinson's disease (PD) (rest tremor, bradykinesia, rigidity). Quantitative motor testing (timed tapping test and Purdue pegboard test) revealed a graded reduction in performance in those clinically found to have clinically possible and clinically probable PD. Longitudinal examinations over 4 years revealed some individuals progressed from control to clinically possible PD and clinically possible PD to clinically probable PD. This study underscores the importance of longitudinal antemortem testing of prospective brain donors as well as the potential value of quantitative motor testing.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 103-110 |
| Number of pages | 8 |
| Journal | Parkinsonism and Related Disorders |
| Volume | 9 |
| Issue number | 2 |
| DOIs | |
| State | Published - Dec 2002 |
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Keywords
- Brain donation
- Motor impairment
- Parkinson's disease
ASJC Scopus subject areas
- Aging
- Clinical Neurology
- Neurology
Cite this
Motor impairment in normal aging, clinically possible Parkinson's disease, and clinically probable Parkinson's disease : Longitudinal evaluation of a cohort of prospective brain donors. / Adler, Charles Howard; Hentz, Joseph G.; Joyce, Jeffrey N.; Beach, Thomas; Caviness, John Nathaniel.
In: Parkinsonism and Related Disorders, Vol. 9, No. 2, 12.2002, p. 103-110.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Motor impairment in normal aging, clinically possible Parkinson's disease, and clinically probable Parkinson's disease
T2 - Longitudinal evaluation of a cohort of prospective brain donors
AU - Adler, Charles Howard
AU - Hentz, Joseph G.
AU - Joyce, Jeffrey N.
AU - Beach, Thomas
AU - Caviness, John Nathaniel
PY - 2002/12
Y1 - 2002/12
N2 - This study presents data on the antemortem evaluations of a cohort of individuals registered in a brain donation program. Clinical evaluation determined that many individuals were unaware they had clinical signs of Parkinson's disease (PD) (rest tremor, bradykinesia, rigidity). Quantitative motor testing (timed tapping test and Purdue pegboard test) revealed a graded reduction in performance in those clinically found to have clinically possible and clinically probable PD. Longitudinal examinations over 4 years revealed some individuals progressed from control to clinically possible PD and clinically possible PD to clinically probable PD. This study underscores the importance of longitudinal antemortem testing of prospective brain donors as well as the potential value of quantitative motor testing.
AB - This study presents data on the antemortem evaluations of a cohort of individuals registered in a brain donation program. Clinical evaluation determined that many individuals were unaware they had clinical signs of Parkinson's disease (PD) (rest tremor, bradykinesia, rigidity). Quantitative motor testing (timed tapping test and Purdue pegboard test) revealed a graded reduction in performance in those clinically found to have clinically possible and clinically probable PD. Longitudinal examinations over 4 years revealed some individuals progressed from control to clinically possible PD and clinically possible PD to clinically probable PD. This study underscores the importance of longitudinal antemortem testing of prospective brain donors as well as the potential value of quantitative motor testing.
KW - Brain donation
KW - Motor impairment
KW - Parkinson's disease
UR - http://www.scopus.com/inward/record.url?scp=1842859016&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=1842859016&partnerID=8YFLogxK
U2 - 10.1016/S1353-8020(02)00012-3
DO - 10.1016/S1353-8020(02)00012-3
M3 - Article
C2 - 12473400
AN - SCOPUS:1842859016
VL - 9
SP - 103
EP - 110
JO - Parkinsonism and Related Disorders
JF - Parkinsonism and Related Disorders
SN - 1353-8020
IS - 2
ER -