Motor impairment in normal aging, clinically possible Parkinson's disease, and clinically probable Parkinson's disease: Longitudinal evaluation of a cohort of prospective brain donors

Charles H. Adler, Joseph G. Hentz, Jeffrey N. Joyce, Thomas Beach, John N. Caviness

Research output: Contribution to journalArticle

31 Scopus citations

Abstract

This study presents data on the antemortem evaluations of a cohort of individuals registered in a brain donation program. Clinical evaluation determined that many individuals were unaware they had clinical signs of Parkinson's disease (PD) (rest tremor, bradykinesia, rigidity). Quantitative motor testing (timed tapping test and Purdue pegboard test) revealed a graded reduction in performance in those clinically found to have clinically possible and clinically probable PD. Longitudinal examinations over 4 years revealed some individuals progressed from control to clinically possible PD and clinically possible PD to clinically probable PD. This study underscores the importance of longitudinal antemortem testing of prospective brain donors as well as the potential value of quantitative motor testing.

Original languageEnglish (US)
Pages (from-to)103-110
Number of pages8
JournalParkinsonism and Related Disorders
Volume9
Issue number2
DOIs
StatePublished - Dec 2002

Keywords

  • Brain donation
  • Motor impairment
  • Parkinson's disease

ASJC Scopus subject areas

  • Neurology
  • Geriatrics and Gerontology
  • Clinical Neurology

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