Motor impairment in normal aging, clinically possible Parkinson's disease, and clinically probable Parkinson's disease: Longitudinal evaluation of a cohort of prospective brain donors

Charles H. Adler; Joseph G. Hentz; Jeffrey N. Joyce; Thomas Beach; John N. Caviness

doi:10.1016/S1353-8020(02)00012-3

Motor impairment in normal aging, clinically possible Parkinson's disease, and clinically probable Parkinson's disease: Longitudinal evaluation of a cohort of prospective brain donors

Charles H. Adler, Joseph G. Hentz, Jeffrey N. Joyce, Thomas Beach, John N. Caviness

Neurology

Research output: Contribution to journal › Article › peer-review

31 Scopus citations

Abstract

This study presents data on the antemortem evaluations of a cohort of individuals registered in a brain donation program. Clinical evaluation determined that many individuals were unaware they had clinical signs of Parkinson's disease (PD) (rest tremor, bradykinesia, rigidity). Quantitative motor testing (timed tapping test and Purdue pegboard test) revealed a graded reduction in performance in those clinically found to have clinically possible and clinically probable PD. Longitudinal examinations over 4 years revealed some individuals progressed from control to clinically possible PD and clinically possible PD to clinically probable PD. This study underscores the importance of longitudinal antemortem testing of prospective brain donors as well as the potential value of quantitative motor testing.

Original language	English (US)
Pages (from-to)	103-110
Number of pages	8
Journal	Parkinsonism and Related Disorders
Volume	9
Issue number	2
DOIs	https://doi.org/10.1016/S1353-8020(02)00012-3
State	Published - Dec 2002

Keywords

Brain donation
Motor impairment
Parkinson's disease

ASJC Scopus subject areas

Neurology
Geriatrics and Gerontology
Clinical Neurology

Access to Document

10.1016/S1353-8020(02)00012-3

Cite this

Motor impairment in normal aging, clinically possible Parkinson's disease, and clinically probable Parkinson's disease: Longitudinal evaluation of a cohort of prospective brain donors. / Adler, Charles H.; Hentz, Joseph G.; Joyce, Jeffrey N. et al.
In: Parkinsonism and Related Disorders, Vol. 9, No. 2, 12.2002, p. 103-110.

Research output: Contribution to journal › Article › peer-review

@article{5e8478c740184950ba61261f8da2db77,

title = "Motor impairment in normal aging, clinically possible Parkinson's disease, and clinically probable Parkinson's disease: Longitudinal evaluation of a cohort of prospective brain donors",

abstract = "This study presents data on the antemortem evaluations of a cohort of individuals registered in a brain donation program. Clinical evaluation determined that many individuals were unaware they had clinical signs of Parkinson's disease (PD) (rest tremor, bradykinesia, rigidity). Quantitative motor testing (timed tapping test and Purdue pegboard test) revealed a graded reduction in performance in those clinically found to have clinically possible and clinically probable PD. Longitudinal examinations over 4 years revealed some individuals progressed from control to clinically possible PD and clinically possible PD to clinically probable PD. This study underscores the importance of longitudinal antemortem testing of prospective brain donors as well as the potential value of quantitative motor testing.",

keywords = "Brain donation, Motor impairment, Parkinson's disease",

author = "Adler, {Charles H.} and Hentz, {Joseph G.} and Joyce, {Jeffrey N.} and Thomas Beach and Caviness, {John N.}",

note = "Funding Information: The authors wish to thank Joseph Rogers, PhD and Marwan Sabbagh, MD for their support and helpful discussions, and Jose Hernandez for statistical assistance. This work was funded by Mayo Foundation and Sun Health Research Institute.",

year = "2002",

month = dec,

doi = "10.1016/S1353-8020(02)00012-3",

language = "English (US)",

volume = "9",

pages = "103--110",

journal = "Parkinsonism and Related Disorders",

issn = "1353-8020",

publisher = "Elsevier BV",

number = "2",

}

TY - JOUR

T1 - Motor impairment in normal aging, clinically possible Parkinson's disease, and clinically probable Parkinson's disease

T2 - Longitudinal evaluation of a cohort of prospective brain donors

AU - Adler, Charles H.

AU - Hentz, Joseph G.

AU - Joyce, Jeffrey N.

AU - Beach, Thomas

AU - Caviness, John N.

N1 - Funding Information: The authors wish to thank Joseph Rogers, PhD and Marwan Sabbagh, MD for their support and helpful discussions, and Jose Hernandez for statistical assistance. This work was funded by Mayo Foundation and Sun Health Research Institute.

PY - 2002/12

Y1 - 2002/12

N2 - This study presents data on the antemortem evaluations of a cohort of individuals registered in a brain donation program. Clinical evaluation determined that many individuals were unaware they had clinical signs of Parkinson's disease (PD) (rest tremor, bradykinesia, rigidity). Quantitative motor testing (timed tapping test and Purdue pegboard test) revealed a graded reduction in performance in those clinically found to have clinically possible and clinically probable PD. Longitudinal examinations over 4 years revealed some individuals progressed from control to clinically possible PD and clinically possible PD to clinically probable PD. This study underscores the importance of longitudinal antemortem testing of prospective brain donors as well as the potential value of quantitative motor testing.

AB - This study presents data on the antemortem evaluations of a cohort of individuals registered in a brain donation program. Clinical evaluation determined that many individuals were unaware they had clinical signs of Parkinson's disease (PD) (rest tremor, bradykinesia, rigidity). Quantitative motor testing (timed tapping test and Purdue pegboard test) revealed a graded reduction in performance in those clinically found to have clinically possible and clinically probable PD. Longitudinal examinations over 4 years revealed some individuals progressed from control to clinically possible PD and clinically possible PD to clinically probable PD. This study underscores the importance of longitudinal antemortem testing of prospective brain donors as well as the potential value of quantitative motor testing.

KW - Brain donation

KW - Motor impairment

KW - Parkinson's disease

UR - http://www.scopus.com/inward/record.url?scp=1842859016&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=1842859016&partnerID=8YFLogxK

U2 - 10.1016/S1353-8020(02)00012-3

DO - 10.1016/S1353-8020(02)00012-3

M3 - Article

C2 - 12473400

AN - SCOPUS:1842859016

SN - 1353-8020

VL - 9

SP - 103

EP - 110

JO - Parkinsonism and Related Disorders

JF - Parkinsonism and Related Disorders

IS - 2

ER -

Motor impairment in normal aging, clinically possible Parkinson's disease, and clinically probable Parkinson's disease: Longitudinal evaluation of a cohort of prospective brain donors

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this