Motor evoked potential monitoring during cryoablation of musculoskeletal tumors

Anil Nicholas Kurup, Jonathan M. Morris, Andrea J. Boon, Jeffrey A. Strommen, Grant D. Schmit, Thomas D. Atwell, Rickey E. Carter, Michael J. Brown, C. Thomas Wass, Peter S. Rose, Matthew R. Callstrom

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45 Scopus citations

Abstract

Purpose: To describe the use of intraprocedural motor evoked potential (MEP) monitoring to minimize risk of neural injury during percutaneous cryoablation of perineural musculoskeletal tumors. Materials and Methods: A single-institution retrospective review of cryoablation procedures performed to treat perineural musculoskeletal tumors with the use of MEP monitoring between May 2011 and March 2013 yielded 59 procedures to treat 64 tumors in 52 patients (26 male). Median age was 61 years (range, 4-82 y). Tumors were located in the spine (n = 27), sacrum (n = 3), retroperitoneum (n = 4), pelvis (n = 22), and extremities (n = 8), and 21 different tumor histologies were represented. Median tumor size was 4.0 cm (range, 0.8-15.0 cm). Total intravenous general anesthesia, computed tomographic guidance, and transcranial MEP monitoring were employed. Patient demographics, tumor characteristics, MEP findings, and clinical outcomes were assessed. Results: Nineteen of 59 procedures (32%) resulted in decreases in intraprocedural MEPs, including 15 (25%) with transient decreases and four (7%) with persistent decreases. Two of the four patients with persistent MEP decreases (50%) had motor deficits following ablation. No functional motor deficit developed in a patient with transient MEP decreases or no MEP change. The risk of major motor injury with persistent MEP changes was significantly increased versus transient or no MEP change (P = .0045; relative risk, 69.8; 95% confidence interval, 5.9 to > 100). MEP decreases were 100% sensitive and 70% specific for the detection of motor deficits. Conclusions: Persistent MEP decreases correlate with postprocedural sustained motor deficits. Intraprocedural MEP monitoring helps predict neural injury and may improve patient safety during cryoablation of perineural musculoskeletal tumors.

Original languageEnglish (US)
Pages (from-to)1657-1664
Number of pages8
JournalJournal of Vascular and Interventional Radiology
Volume25
Issue number11
StatePublished - Jan 1 2014

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ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Cardiology and Cardiovascular Medicine

Cite this

Kurup, A. N., Morris, J. M., Boon, A. J., Strommen, J. A., Schmit, G. D., Atwell, T. D., Carter, R. E., Brown, M. J., Wass, C. T., Rose, P. S., & Callstrom, M. R. (2014). Motor evoked potential monitoring during cryoablation of musculoskeletal tumors. Journal of Vascular and Interventional Radiology, 25(11), 1657-1664.