Motor dysfunction of the small bowel and colon in patients with the carcinoid syndrome and diarrhea

M. R. Von der Ohe, Michael Camilleri, L. K. Kvols, G. M. Thomforde

Research output: Contribution to journalArticle

139 Citations (Scopus)

Abstract

Background and Methods. The pathophysiology of diarrhea in patients with the carcinoid syndrome is not understood. Possible causes include tumor production of neurohumoral substances, such as serotonin and substance P, which stimulate small-bowel and colonic motility, and intestinal abnormalities, such as lymphangiectasia and bacterial overgrowth. We undertook this study to determine whether carcinoid diarrhea is associated with abnormal motor function in the small intestine and colon. We measured the gastric, small-bowel, and colonic transit of radiolabeled solid residue and estimated the volume of the ascending colon in 16 patients with the carcinoid syndrome and diarrhea and 16 normal subjects. We also measured colonic tone and phasic pressure activity by intracolonic multilumen manometry and with an electronic barostat in seven patients and six normal subjects. Results. The patients with the carcinoid syndrome had elevated 24- hour urinary excretion of 5-hydroxyindoleacetic acid and elevated fasting plasma serotonin concentrations. Transit times in the small bowel and colon were two times (P

Original languageEnglish (US)
Pages (from-to)1073-1078
Number of pages6
JournalNew England Journal of Medicine
Volume329
Issue number15
DOIs
StatePublished - 1993

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Carcinoid Tumor
Diarrhea
Colon
Serotonin
Lymphangiectasis
Ascending Colon
Hydroxyindoleacetic Acid
Gastrointestinal Motility
Manometry
Substance P
Small Intestine
Fasting
Stomach
Pressure
Neoplasms

ASJC Scopus subject areas

  • Medicine(all)

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Motor dysfunction of the small bowel and colon in patients with the carcinoid syndrome and diarrhea. / Von der Ohe, M. R.; Camilleri, Michael; Kvols, L. K.; Thomforde, G. M.

In: New England Journal of Medicine, Vol. 329, No. 15, 1993, p. 1073-1078.

Research output: Contribution to journalArticle

Von der Ohe, M. R. ; Camilleri, Michael ; Kvols, L. K. ; Thomforde, G. M. / Motor dysfunction of the small bowel and colon in patients with the carcinoid syndrome and diarrhea. In: New England Journal of Medicine. 1993 ; Vol. 329, No. 15. pp. 1073-1078.
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