Several studies have linked intraplaque neovascularization (IPN) with progressive atherosclerotic disease and plaque instability. An accurate quantification of IPN may allow early detection of vulnerable plaques. In this study, a dedicated motion compensation method was developed for quantification of IPN in small plaques (<30% diameter stenosis). Motion compensation is a prerequisite to analyze identical regions of interest (ROI) for accurate quantification of IPN. Side-by-side CEUS and B-mode ultrasound images of carotid arteries were acquired by a Philips iU22 system with a L9-3 linear array probe. The motion pattern for the plaque region was obtained from the B-mode images with a tuned speckle tracking (ST) method with subpixel precision and applied to contrast images. In-vivo validation was done by comparing ST to manual tracking by two experts for multibeat image sequences (MIS) of 11 plaques. In the in-vivo validation, error was 51.4 ± 91 μm for X (longitudinal) and 18.7 ± 39.8 μm for Y (radial). The ST success rate was visually assessed on 67 atherosclerotic wall plaque MIS. The tracking was considered failed if the ST deviated > 2 pixels from true motion in any frame. Tracking was scored as fully successful in 52 MIS (78%). The proposed motion tracking is sufficiently accurate and successful for in vivo application.