Motion analysis of right ventricular dysfunction under mild or moderate pressure overload caused by acute pulmonary embolism

Nima Tajbakhsh, Hong Wu, Wenzhe Xue, Eileen M. McMahon, Marek Belohlavek, Jianming Liang

Research output: Contribution to journalArticle

Abstract

Acute pulmonary embolism (APE) is the third most common cause of death in the United States. Appearing as a sudden blockage in a major pulmonary artery, APE may cause mild, moderate or severe right ventricular (RV) overload. Although severe RV overload produces diagnostically obvious RV mechanical failure, little progress has been made in gaining a clinical and biophysical understanding of moderate and mild acute RV overload and its impact on RV functionality. In the research described here, we conducted a pilot study in pigs using echocardiography and observed the following abnormalities in RV functionality under acute mild or moderate RV overload: (i) occurrence of paradoxical septal motion with "waving" dynamics; (ii) decrease in local curvature of the septum (p<0.01); (iii) lower positive correlation between movement of the RV free wall and movement of the septum (p<0.05); (iv) slower rate of RV fractional area change (p<0.05); and (v) decrease in movement stability, particularly in the middle of the septum (p<0.05).

Original languageEnglish (US)
Pages (from-to)2066-2074
Number of pages9
JournalUltrasound in Medicine and Biology
Volume39
Issue number11
DOIs
StatePublished - Nov 2013

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embolisms
Right Ventricular Dysfunction
Pulmonary Embolism
septum
Pressure
Pulmonary Artery
Echocardiography
Cause of Death
Swine
echocardiography
swine
causes
abnormalities
arteries
Research
death
curvature
occurrences

Keywords

  • Active contours
  • Acute pulmonary embolism
  • Biomarker
  • Mild or moderate right ventricular pressure overload
  • Motion analysis
  • Paradoxical septal motion
  • Rate of right ventricular transverse fractional area change

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology
  • Biophysics

Cite this

Motion analysis of right ventricular dysfunction under mild or moderate pressure overload caused by acute pulmonary embolism. / Tajbakhsh, Nima; Wu, Hong; Xue, Wenzhe; McMahon, Eileen M.; Belohlavek, Marek; Liang, Jianming.

In: Ultrasound in Medicine and Biology, Vol. 39, No. 11, 11.2013, p. 2066-2074.

Research output: Contribution to journalArticle

Tajbakhsh, Nima ; Wu, Hong ; Xue, Wenzhe ; McMahon, Eileen M. ; Belohlavek, Marek ; Liang, Jianming. / Motion analysis of right ventricular dysfunction under mild or moderate pressure overload caused by acute pulmonary embolism. In: Ultrasound in Medicine and Biology. 2013 ; Vol. 39, No. 11. pp. 2066-2074.
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