Motility abnormalities in gastroesophageal reflux disease

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

Esophageal dysmotility occurs in association with GERD; however, the cause of these motility abnormalities is not known. It is also not clear whether injury results from the presence of acid itself, inflammatory change or fibrosisin the esophageal wall. It is also unclear if reversal of these abnormalities takes place, and if so, to what degree. There are, however, a subset of patients who seem to have improvement with effective medical or surgical therapy, parodoxically, the same patients in whom a fundoplication, particularly a complete wrap, would lead to severe postoperative dysphagia secondary to preoperative dysmotility. What does all this mean for the individual patient? It is likely that most will not have any important change in esophageal motility abnormalities with standard medical or surgical therapy. Fundoplication might be safely performed in patients with minimal motility abnormalities, but those with severe abnormalities should be approached with caution. The conservative approach is to perform a partial fundoplication (Toupet) in those with ineffective motility (>30% low- amplitude or nontransmitted contractions). It is hoped that future investigations will aid in understanding the pathogenesis of these abnormalities and how they can be used more precisely to guide antireflux therapy.

Original languageEnglish (US)
Pages (from-to)905-915
Number of pages11
JournalGastroenterology Clinics of North America
Volume28
Issue number4
DOIs
StatePublished - 1999
Externally publishedYes

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Gastroesophageal Reflux
Fundoplication
Esophageal Motility Disorders
Deglutition Disorders
Therapeutics
Acids
Wounds and Injuries

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Motility abnormalities in gastroesophageal reflux disease. / Katzka, David A.

In: Gastroenterology Clinics of North America, Vol. 28, No. 4, 1999, p. 905-915.

Research output: Contribution to journalArticle

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