TY - JOUR
T1 - Mortality Risk Factors among Infants Receiving Dialysis in the Neonatal Intensive Care Unit
AU - Sanderson, Keia R.
AU - Warady, Bradley
AU - Carey, William
AU - Tolia, Veeral
AU - Boynton, Marcella H.
AU - Benjamin, Daniel K.
AU - Jackson, Wesley
AU - Laughon, Matthew
AU - Clark, Reese H.
AU - Greenberg, Rachel G.
N1 - Publisher Copyright:
© 2021 Elsevier Inc.
PY - 2022/3
Y1 - 2022/3
N2 - Objectives: To identify risk factors associated with mortality for infants receiving dialysis in the neonatal intensive care unit (NICU). Study design: In this retrospective cohort study, we extracted data from the Pediatrix Clinical Data Warehouse on all infants who received dialysis in the NICU from 1999 to 2018. Using a Cox proportional hazards model with robust SEs we estimated the mortality hazard ratios associated with demographics, birth details, medical complications, and treatment exposures. Results: We identified 273 infants who received dialysis. Median gestational age at birth was 35 weeks (interquartile values 33-37), median birth weight was 2570 g (2000-3084), 8% were small for gestational age, 41% white, and 72% male. Over one-half of the infants (59%) had a kidney anomaly; 71 (26%) infants died before NICU hospital discharge. Factors associated with increased risk of dying after dialysis initiation included lack of kidney anomalies, Black race, gestational age of <32 weeks, necrotizing enterocolitis, dialysis within 7 days of life, and receipt of paralytics or vasopressors (all P <.05). Conclusion: In this cohort of infants who received dialysis in the NICU over 2 decades, more than 70% of infants survived. The probability of death was greater among infants without a history of a kidney anomaly and those with risk factors consistent with greater severity of illness at dialysis initiation.
AB - Objectives: To identify risk factors associated with mortality for infants receiving dialysis in the neonatal intensive care unit (NICU). Study design: In this retrospective cohort study, we extracted data from the Pediatrix Clinical Data Warehouse on all infants who received dialysis in the NICU from 1999 to 2018. Using a Cox proportional hazards model with robust SEs we estimated the mortality hazard ratios associated with demographics, birth details, medical complications, and treatment exposures. Results: We identified 273 infants who received dialysis. Median gestational age at birth was 35 weeks (interquartile values 33-37), median birth weight was 2570 g (2000-3084), 8% were small for gestational age, 41% white, and 72% male. Over one-half of the infants (59%) had a kidney anomaly; 71 (26%) infants died before NICU hospital discharge. Factors associated with increased risk of dying after dialysis initiation included lack of kidney anomalies, Black race, gestational age of <32 weeks, necrotizing enterocolitis, dialysis within 7 days of life, and receipt of paralytics or vasopressors (all P <.05). Conclusion: In this cohort of infants who received dialysis in the NICU over 2 decades, more than 70% of infants survived. The probability of death was greater among infants without a history of a kidney anomaly and those with risk factors consistent with greater severity of illness at dialysis initiation.
KW - acute kidney injury
KW - chronic kidney disease
KW - continuous kidney replacement therapy
KW - dialysis
KW - neonatal
KW - peritoneal dialysis
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U2 - 10.1016/j.jpeds.2021.11.025
DO - 10.1016/j.jpeds.2021.11.025
M3 - Article
C2 - 34798078
AN - SCOPUS:85122516869
SN - 0022-3476
VL - 242
SP - 159
EP - 165
JO - Journal of Pediatrics
JF - Journal of Pediatrics
ER -