Mortality in patients with Parkinson's disease treated by stimulation of the subthalamic nucleus

Michael W.M. Schüpbach; Marie Laure Welter; Anne Marie Bonnet; Alexis Elbaz; Brandon R. Grossardt; Valerie Mesnage; Jean Luc Houeto; David Maltête; Luc Mallet; Walter A. Rocca; Alain Mallet; Yves Agid

doi:10.1002/mds.21264

Mortality in patients with Parkinson's disease treated by stimulation of the subthalamic nucleus

Michael W.M. Schüpbach, Marie Laure Welter, Anne Marie Bonnet, Alexis Elbaz, Brandon R. Grossardt, Valerie Mesnage, Jean Luc Houeto, David Maltête, Luc Mallet, Walter A. Rocca, Alain Mallet, Yves Agid

Quantitative Health Sciences

Research output: Contribution to journal › Article › peer-review

20 Scopus citations

Abstract

Suhthalamic nucleus (STN) stimulation improves motor disability and quality of life in patients with advanced Parkinson's disease (PD). Short-term mortality is low, but little is known about long-term mortality. We assessed mortality and causes of death in 171 consecutive PD patients treated by STN stimulation. Surgery was performed after a median lagtime of 13 years from PD onset at a median age of 57 years. The median follow-up after surgery was 41 months. Sixteen patients died 8 to 83 months after neurosurgery. Poorer cognitive function was the only predictive factor for mortality (standardized mortality ratio = 2.9; 95% confidence interval [CI], 1.6-4.7; P < 0.0001). Based on a historical comparison of 118 operated patients with 39 nonoperated patients from a different population, survival among operated patients was not better (hazard ratio = 1.2; 95% CI, 0.7-2.1).

Original language	English (US)
Pages (from-to)	257-261
Number of pages	5
Journal	Movement Disorders
Volume	22
Issue number	2
DOIs	https://doi.org/10.1002/mds.21264
State	Published - Jan 15 2007

Keywords

Deep brain stimulation
Mortality
Parkinson's disease
Subthalamic nucleus

ASJC Scopus subject areas

Neurology
Clinical Neurology

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10.1002/mds.21264

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title = "Mortality in patients with Parkinson's disease treated by stimulation of the subthalamic nucleus",

abstract = "Suhthalamic nucleus (STN) stimulation improves motor disability and quality of life in patients with advanced Parkinson's disease (PD). Short-term mortality is low, but little is known about long-term mortality. We assessed mortality and causes of death in 171 consecutive PD patients treated by STN stimulation. Surgery was performed after a median lagtime of 13 years from PD onset at a median age of 57 years. The median follow-up after surgery was 41 months. Sixteen patients died 8 to 83 months after neurosurgery. Poorer cognitive function was the only predictive factor for mortality (standardized mortality ratio = 2.9; 95% confidence interval [CI], 1.6-4.7; P < 0.0001). Based on a historical comparison of 118 operated patients with 39 nonoperated patients from a different population, survival among operated patients was not better (hazard ratio = 1.2; 95% CI, 0.7-2.1).",

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AU - Schüpbach, Michael W.M.

AU - Welter, Marie Laure

AU - Bonnet, Anne Marie

AU - Elbaz, Alexis

AU - Grossardt, Brandon R.

AU - Mesnage, Valerie

AU - Houeto, Jean Luc

AU - Maltête, David

AU - Mallet, Luc

AU - Rocca, Walter A.

AU - Mallet, Alain

AU - Agid, Yves

PY - 2007/1/15

Y1 - 2007/1/15

N2 - Suhthalamic nucleus (STN) stimulation improves motor disability and quality of life in patients with advanced Parkinson's disease (PD). Short-term mortality is low, but little is known about long-term mortality. We assessed mortality and causes of death in 171 consecutive PD patients treated by STN stimulation. Surgery was performed after a median lagtime of 13 years from PD onset at a median age of 57 years. The median follow-up after surgery was 41 months. Sixteen patients died 8 to 83 months after neurosurgery. Poorer cognitive function was the only predictive factor for mortality (standardized mortality ratio = 2.9; 95% confidence interval [CI], 1.6-4.7; P < 0.0001). Based on a historical comparison of 118 operated patients with 39 nonoperated patients from a different population, survival among operated patients was not better (hazard ratio = 1.2; 95% CI, 0.7-2.1).

AB - Suhthalamic nucleus (STN) stimulation improves motor disability and quality of life in patients with advanced Parkinson's disease (PD). Short-term mortality is low, but little is known about long-term mortality. We assessed mortality and causes of death in 171 consecutive PD patients treated by STN stimulation. Surgery was performed after a median lagtime of 13 years from PD onset at a median age of 57 years. The median follow-up after surgery was 41 months. Sixteen patients died 8 to 83 months after neurosurgery. Poorer cognitive function was the only predictive factor for mortality (standardized mortality ratio = 2.9; 95% confidence interval [CI], 1.6-4.7; P < 0.0001). Based on a historical comparison of 118 operated patients with 39 nonoperated patients from a different population, survival among operated patients was not better (hazard ratio = 1.2; 95% CI, 0.7-2.1).

KW - Deep brain stimulation

KW - Mortality

KW - Parkinson's disease

KW - Subthalamic nucleus

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Mortality in patients with Parkinson's disease treated by stimulation of the subthalamic nucleus

Abstract

Keywords

ASJC Scopus subject areas

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