Mortality in patients with Parkinson's disease treated by stimulation of the subthalamic nucleus

Michael W.M. Schüpbach, Marie Laure Welter, Anne Marie Bonnet, Alexis Elbaz, Brandon R. Grossardt, Valerie Mesnage, Jean Luc Houeto, David Maltête, Luc Mallet, Walter A. Rocca, Alain Mallet, Yves Agid

Research output: Contribution to journalArticle

15 Scopus citations

Abstract

Suhthalamic nucleus (STN) stimulation improves motor disability and quality of life in patients with advanced Parkinson's disease (PD). Short-term mortality is low, but little is known about long-term mortality. We assessed mortality and causes of death in 171 consecutive PD patients treated by STN stimulation. Surgery was performed after a median lagtime of 13 years from PD onset at a median age of 57 years. The median follow-up after surgery was 41 months. Sixteen patients died 8 to 83 months after neurosurgery. Poorer cognitive function was the only predictive factor for mortality (standardized mortality ratio = 2.9; 95% confidence interval [CI], 1.6-4.7; P < 0.0001). Based on a historical comparison of 118 operated patients with 39 nonoperated patients from a different population, survival among operated patients was not better (hazard ratio = 1.2; 95% CI, 0.7-2.1).

Original languageEnglish (US)
Pages (from-to)257-261
Number of pages5
JournalMovement Disorders
Volume22
Issue number2
DOIs
StatePublished - Jan 15 2007

Keywords

  • Deep brain stimulation
  • Mortality
  • Parkinson's disease
  • Subthalamic nucleus

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

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    Schüpbach, M. W. M., Welter, M. L., Bonnet, A. M., Elbaz, A., Grossardt, B. R., Mesnage, V., Houeto, J. L., Maltête, D., Mallet, L., Rocca, W. A., Mallet, A., & Agid, Y. (2007). Mortality in patients with Parkinson's disease treated by stimulation of the subthalamic nucleus. Movement Disorders, 22(2), 257-261. https://doi.org/10.1002/mds.21264