Mortality in patients with Parkinson's disease treated by stimulation of the subthalamic nucleus

M. W M Schüpbach, Marie Laure Welter, Anne Marie Bonnet, Alexis Elbaz, Brandon R. Grossardt, Valerie Mesnage, Jean Luc Houeto, David Maltête, Luc Mallet, Walter A Rocca, Alain Mallet, Yves Agid

Research output: Contribution to journalArticle

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Abstract

Suhthalamic nucleus (STN) stimulation improves motor disability and quality of life in patients with advanced Parkinson's disease (PD). Short-term mortality is low, but little is known about long-term mortality. We assessed mortality and causes of death in 171 consecutive PD patients treated by STN stimulation. Surgery was performed after a median lagtime of 13 years from PD onset at a median age of 57 years. The median follow-up after surgery was 41 months. Sixteen patients died 8 to 83 months after neurosurgery. Poorer cognitive function was the only predictive factor for mortality (standardized mortality ratio = 2.9; 95% confidence interval [CI], 1.6-4.7; P < 0.0001). Based on a historical comparison of 118 operated patients with 39 nonoperated patients from a different population, survival among operated patients was not better (hazard ratio = 1.2; 95% CI, 0.7-2.1).

Original languageEnglish (US)
Pages (from-to)257-261
Number of pages5
JournalMovement Disorders
Volume22
Issue number2
DOIs
StatePublished - Jan 15 2007

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Subthalamic Nucleus
Parkinson Disease
Mortality
Confidence Intervals
Neurosurgery
Cognition
Cause of Death
Quality of Life
Survival
Population

Keywords

  • Deep brain stimulation
  • Mortality
  • Parkinson's disease
  • Subthalamic nucleus

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)

Cite this

Schüpbach, M. W. M., Welter, M. L., Bonnet, A. M., Elbaz, A., Grossardt, B. R., Mesnage, V., ... Agid, Y. (2007). Mortality in patients with Parkinson's disease treated by stimulation of the subthalamic nucleus. Movement Disorders, 22(2), 257-261. https://doi.org/10.1002/mds.21264

Mortality in patients with Parkinson's disease treated by stimulation of the subthalamic nucleus. / Schüpbach, M. W M; Welter, Marie Laure; Bonnet, Anne Marie; Elbaz, Alexis; Grossardt, Brandon R.; Mesnage, Valerie; Houeto, Jean Luc; Maltête, David; Mallet, Luc; Rocca, Walter A; Mallet, Alain; Agid, Yves.

In: Movement Disorders, Vol. 22, No. 2, 15.01.2007, p. 257-261.

Research output: Contribution to journalArticle

Schüpbach, MWM, Welter, ML, Bonnet, AM, Elbaz, A, Grossardt, BR, Mesnage, V, Houeto, JL, Maltête, D, Mallet, L, Rocca, WA, Mallet, A & Agid, Y 2007, 'Mortality in patients with Parkinson's disease treated by stimulation of the subthalamic nucleus', Movement Disorders, vol. 22, no. 2, pp. 257-261. https://doi.org/10.1002/mds.21264
Schüpbach MWM, Welter ML, Bonnet AM, Elbaz A, Grossardt BR, Mesnage V et al. Mortality in patients with Parkinson's disease treated by stimulation of the subthalamic nucleus. Movement Disorders. 2007 Jan 15;22(2):257-261. https://doi.org/10.1002/mds.21264
Schüpbach, M. W M ; Welter, Marie Laure ; Bonnet, Anne Marie ; Elbaz, Alexis ; Grossardt, Brandon R. ; Mesnage, Valerie ; Houeto, Jean Luc ; Maltête, David ; Mallet, Luc ; Rocca, Walter A ; Mallet, Alain ; Agid, Yves. / Mortality in patients with Parkinson's disease treated by stimulation of the subthalamic nucleus. In: Movement Disorders. 2007 ; Vol. 22, No. 2. pp. 257-261.
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