Mortality in hypereosinophilic syndrome: 19 years of experience at Mayo Clinic with a review of the literature

Jenna C. Podjasek, Joseph H. Butterfield

Research output: Contribution to journalArticle

38 Scopus citations


Background: Information in the literature regarding causes of mortality in patients with hypereosinophilic syndrome (HES) is limited. Methods: This was a retrospective review of the morbidities and causes of death in HES patients at Mayo Clinic. Results: Overall, out of the 247 diagnosed HES patients, 23 died during the 19 years that this review encompassed. The cause of death was identified in 15 patients (65%): cardiac dysfunction in 5 (33%), infection in 3 (20%), unrelated malignancy in 3 (20%), thromboembolic phenomena in 2 (13%), and vascular disease in 2 (13%). Conclusion: Targeted monitoring of the at-risk end organs, combined with early treatment, may have the ability to improve survival and reduce morbidity in HES patients.

Original languageEnglish (US)
Pages (from-to)392-395
Number of pages4
JournalLeukemia Research
Issue number4
StatePublished - Apr 1 2013



  • Cause of death
  • Eosinophilia
  • Hypereosinophilia
  • Hypereosinophilic syndrome
  • Mortality

ASJC Scopus subject areas

  • Hematology
  • Oncology
  • Cancer Research

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