Mortality in amnestic mild cognitive impairment: A prospective community study

A. L. Hunderfund, Rosebud O Roberts, T. C. Slusser, C. L. Leibson, Yonas Endale Geda, R. J. Ivnik, Eric George Tangalos, Ronald Carl Petersen

Research output: Contribution to journalArticle

44 Citations (Scopus)

Abstract

OBJECTIVE: To assess the hazard of death in persons with and without amnestic mild cognitive impairment (aMCI). METHODS: From 1987 through 2003, persons with aMCI (n = 243) and an age- and gender-matched reference group of cognitively normal persons in Olmsted County, MN, were recruited through the Mayo Clinic Alzheimer's Disease Patient Registry and followed prospectively through 2004. Survival was estimated using Kaplan-Meier survival curves, and the hazard of death for the aMCI cohort vs the reference cohort was estimated using Cox proportional hazards models. RESULTS: Over a median follow-up of 5.7 years, persons with aMCI had increased mortality (hazard ratio [HR] = 1.7; 95% CI: 1.3 to 2.3) vs reference subjects. The hazard of death by aMCI subtype was 1.5 in persons with single-domain aMCI (95% CI: 1.1 to 2.1) and 2.9 in persons with multiple-domain aMCI (95% CI: 1.9 to 4.6) vs reference subjects. Analyses restricted to aMCI cases showed an interaction between aMCI subtype and APOE-ϵ4 allele status (p = 0.003). Among aMCI cases with an APOE-ϵ4 allele, there was no difference in mortality between single- and multiple-domain aMCI (HR = 1.2; 95% CI: 0.6 to 2.3). However, among aMCI cases with no APOE-ϵ4 allele, the hazard of death in multiple-domain aMCI was 4.6 (95% CI: 2.3 to 9.1) vs single-domain aMCI. CONCLUSIONS: Amnestic mild cognitive impairment is associated with increased mortality, which is greater in multiple-domain aMCI than in single-domain aMCI. Mortality in aMCI subtypes may vary by APOE-ϵ4 allele status.

Original languageEnglish (US)
Pages (from-to)1764-1768
Number of pages5
JournalNeurology
Volume67
Issue number10
DOIs
StatePublished - Nov 2006

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Prospective Studies
Mortality
Alleles
Cognitive Dysfunction
Kaplan-Meier Estimate
Proportional Hazards Models
Registries
Alzheimer Disease
Research Design

ASJC Scopus subject areas

  • Neuroscience(all)

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Mortality in amnestic mild cognitive impairment : A prospective community study. / Hunderfund, A. L.; Roberts, Rosebud O; Slusser, T. C.; Leibson, C. L.; Geda, Yonas Endale; Ivnik, R. J.; Tangalos, Eric George; Petersen, Ronald Carl.

In: Neurology, Vol. 67, No. 10, 11.2006, p. 1764-1768.

Research output: Contribution to journalArticle

Hunderfund AL, Roberts RO, Slusser TC, Leibson CL, Geda YE, Ivnik RJ et al. Mortality in amnestic mild cognitive impairment: A prospective community study. Neurology. 2006 Nov;67(10):1764-1768. https://doi.org/10.1212/01.wnl.0000244430.39969.5f
Hunderfund, A. L. ; Roberts, Rosebud O ; Slusser, T. C. ; Leibson, C. L. ; Geda, Yonas Endale ; Ivnik, R. J. ; Tangalos, Eric George ; Petersen, Ronald Carl. / Mortality in amnestic mild cognitive impairment : A prospective community study. In: Neurology. 2006 ; Vol. 67, No. 10. pp. 1764-1768.
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abstract = "OBJECTIVE: To assess the hazard of death in persons with and without amnestic mild cognitive impairment (aMCI). METHODS: From 1987 through 2003, persons with aMCI (n = 243) and an age- and gender-matched reference group of cognitively normal persons in Olmsted County, MN, were recruited through the Mayo Clinic Alzheimer's Disease Patient Registry and followed prospectively through 2004. Survival was estimated using Kaplan-Meier survival curves, and the hazard of death for the aMCI cohort vs the reference cohort was estimated using Cox proportional hazards models. RESULTS: Over a median follow-up of 5.7 years, persons with aMCI had increased mortality (hazard ratio [HR] = 1.7; 95{\%} CI: 1.3 to 2.3) vs reference subjects. The hazard of death by aMCI subtype was 1.5 in persons with single-domain aMCI (95{\%} CI: 1.1 to 2.1) and 2.9 in persons with multiple-domain aMCI (95{\%} CI: 1.9 to 4.6) vs reference subjects. Analyses restricted to aMCI cases showed an interaction between aMCI subtype and APOE-ϵ4 allele status (p = 0.003). Among aMCI cases with an APOE-ϵ4 allele, there was no difference in mortality between single- and multiple-domain aMCI (HR = 1.2; 95{\%} CI: 0.6 to 2.3). However, among aMCI cases with no APOE-ϵ4 allele, the hazard of death in multiple-domain aMCI was 4.6 (95{\%} CI: 2.3 to 9.1) vs single-domain aMCI. CONCLUSIONS: Amnestic mild cognitive impairment is associated with increased mortality, which is greater in multiple-domain aMCI than in single-domain aMCI. Mortality in aMCI subtypes may vary by APOE-ϵ4 allele status.",
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T1 - Mortality in amnestic mild cognitive impairment

T2 - A prospective community study

AU - Hunderfund, A. L.

AU - Roberts, Rosebud O

AU - Slusser, T. C.

AU - Leibson, C. L.

AU - Geda, Yonas Endale

AU - Ivnik, R. J.

AU - Tangalos, Eric George

AU - Petersen, Ronald Carl

PY - 2006/11

Y1 - 2006/11

N2 - OBJECTIVE: To assess the hazard of death in persons with and without amnestic mild cognitive impairment (aMCI). METHODS: From 1987 through 2003, persons with aMCI (n = 243) and an age- and gender-matched reference group of cognitively normal persons in Olmsted County, MN, were recruited through the Mayo Clinic Alzheimer's Disease Patient Registry and followed prospectively through 2004. Survival was estimated using Kaplan-Meier survival curves, and the hazard of death for the aMCI cohort vs the reference cohort was estimated using Cox proportional hazards models. RESULTS: Over a median follow-up of 5.7 years, persons with aMCI had increased mortality (hazard ratio [HR] = 1.7; 95% CI: 1.3 to 2.3) vs reference subjects. The hazard of death by aMCI subtype was 1.5 in persons with single-domain aMCI (95% CI: 1.1 to 2.1) and 2.9 in persons with multiple-domain aMCI (95% CI: 1.9 to 4.6) vs reference subjects. Analyses restricted to aMCI cases showed an interaction between aMCI subtype and APOE-ϵ4 allele status (p = 0.003). Among aMCI cases with an APOE-ϵ4 allele, there was no difference in mortality between single- and multiple-domain aMCI (HR = 1.2; 95% CI: 0.6 to 2.3). However, among aMCI cases with no APOE-ϵ4 allele, the hazard of death in multiple-domain aMCI was 4.6 (95% CI: 2.3 to 9.1) vs single-domain aMCI. CONCLUSIONS: Amnestic mild cognitive impairment is associated with increased mortality, which is greater in multiple-domain aMCI than in single-domain aMCI. Mortality in aMCI subtypes may vary by APOE-ϵ4 allele status.

AB - OBJECTIVE: To assess the hazard of death in persons with and without amnestic mild cognitive impairment (aMCI). METHODS: From 1987 through 2003, persons with aMCI (n = 243) and an age- and gender-matched reference group of cognitively normal persons in Olmsted County, MN, were recruited through the Mayo Clinic Alzheimer's Disease Patient Registry and followed prospectively through 2004. Survival was estimated using Kaplan-Meier survival curves, and the hazard of death for the aMCI cohort vs the reference cohort was estimated using Cox proportional hazards models. RESULTS: Over a median follow-up of 5.7 years, persons with aMCI had increased mortality (hazard ratio [HR] = 1.7; 95% CI: 1.3 to 2.3) vs reference subjects. The hazard of death by aMCI subtype was 1.5 in persons with single-domain aMCI (95% CI: 1.1 to 2.1) and 2.9 in persons with multiple-domain aMCI (95% CI: 1.9 to 4.6) vs reference subjects. Analyses restricted to aMCI cases showed an interaction between aMCI subtype and APOE-ϵ4 allele status (p = 0.003). Among aMCI cases with an APOE-ϵ4 allele, there was no difference in mortality between single- and multiple-domain aMCI (HR = 1.2; 95% CI: 0.6 to 2.3). However, among aMCI cases with no APOE-ϵ4 allele, the hazard of death in multiple-domain aMCI was 4.6 (95% CI: 2.3 to 9.1) vs single-domain aMCI. CONCLUSIONS: Amnestic mild cognitive impairment is associated with increased mortality, which is greater in multiple-domain aMCI than in single-domain aMCI. Mortality in aMCI subtypes may vary by APOE-ϵ4 allele status.

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