TY - JOUR
T1 - Mortality from papillary thyroid carcinoma
T2 - A case‐control study of 56 lethal cases
AU - Smith, Steven A.
AU - Hay, Ian D.
AU - Goellner, John R.
AU - Ryan, John J.
AU - McConahey, William M.
PY - 1988/10/1
Y1 - 1988/10/1
N2 - To document the presentation, findings, therapy, and postoperative course of lethal papillary thyroid carcinoma (PTC), 56 fatal cases were studied in a retrospective case‐matched control fashion. These patients and their controls were taken from a larger series receiving their primary treatment at one institution (Mayo Clinic; 1946–1970). Mean follow‐up for the lethal cohort was 8.5 years and 16.6 years for controls. Age, sex, tumor size, histologic grade, extent of disease at presentation, European Organization for Research on Treatment of Cancer (EORTC) and AGES scores (patient's age, tumor grade, tumor extent, and tumor size), and DNA ploidy pattern were found to be significant prognostic factors. The immediate causes of death were most frequently either local airway obstruction or respiratory insufficiency from pulmonary metastases. The results suggest that it is possible, at the time of initial treatment, to assess an individual patient's risk of dying from PTC. Aggressive postoperative adjunctive therapy should be restricted to that minority of patients who are at highest risk of death from PTC.
AB - To document the presentation, findings, therapy, and postoperative course of lethal papillary thyroid carcinoma (PTC), 56 fatal cases were studied in a retrospective case‐matched control fashion. These patients and their controls were taken from a larger series receiving their primary treatment at one institution (Mayo Clinic; 1946–1970). Mean follow‐up for the lethal cohort was 8.5 years and 16.6 years for controls. Age, sex, tumor size, histologic grade, extent of disease at presentation, European Organization for Research on Treatment of Cancer (EORTC) and AGES scores (patient's age, tumor grade, tumor extent, and tumor size), and DNA ploidy pattern were found to be significant prognostic factors. The immediate causes of death were most frequently either local airway obstruction or respiratory insufficiency from pulmonary metastases. The results suggest that it is possible, at the time of initial treatment, to assess an individual patient's risk of dying from PTC. Aggressive postoperative adjunctive therapy should be restricted to that minority of patients who are at highest risk of death from PTC.
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U2 - 10.1002/1097-0142(19881001)62:7<1381::AID-CNCR2820620724>3.0.CO;2-R
DO - 10.1002/1097-0142(19881001)62:7<1381::AID-CNCR2820620724>3.0.CO;2-R
M3 - Article
C2 - 3416277
AN - SCOPUS:0023707083
SN - 0008-543X
VL - 62
SP - 1381
EP - 1388
JO - Cancer
JF - Cancer
IS - 7
ER -