Mortality from papillary thyroid carcinoma. A case-control study of 56 lethal cases

S. A. Smith, Ian D Hay, J. R. Goellner, J. J. Ryan, W. M. McConahey

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Abstract

To document the presentation, findings, therapy, and postoperative course of lethal papillary thyroid carcinoma (PTC), 56 fatal cases were studied in a retrospective case-matched control fashion. These patients and their controls were taken from a larger series receiving their primary treatment at one institution (Mayo Clinic; 1946-1970). Mean follow-up for the lethal cohort was 8.5 years and 16.6 years for controls. Age, sex, tumor size, histologic grade, extent of disease at presentation, European Organization for Research on Treatment of Cancer (EORTC) and AGES scores (patient's age, tumor grade, tumor extent, and tumor size), and DNA ploidy pattern were found to be significant prognostic factors. The immediate causes of death were most frequently either local airway obstruction or respiratory insufficiency from pulmonary metastases. The results suggest that it is possible, at the time of initial treatment, to assess an individual patient's risk of dying from PTC. Aggressive postoperative adjunctive therapy should be restricted to that minority of patients who are at highest risk of death from PTC.

Original languageEnglish (US)
Pages (from-to)1381-1388
Number of pages8
JournalCancer
Volume62
Issue number7
StatePublished - 1988

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Case-Control Studies
Mortality
Neoplasms
Therapeutics
Ploidies
Airway Obstruction
Respiratory Insufficiency
Cause of Death
Papillary Thyroid cancer
Organizations
Neoplasm Metastasis
Lung
DNA
Research

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Smith, S. A., Hay, I. D., Goellner, J. R., Ryan, J. J., & McConahey, W. M. (1988). Mortality from papillary thyroid carcinoma. A case-control study of 56 lethal cases. Cancer, 62(7), 1381-1388.

Mortality from papillary thyroid carcinoma. A case-control study of 56 lethal cases. / Smith, S. A.; Hay, Ian D; Goellner, J. R.; Ryan, J. J.; McConahey, W. M.

In: Cancer, Vol. 62, No. 7, 1988, p. 1381-1388.

Research output: Contribution to journalArticle

Smith, SA, Hay, ID, Goellner, JR, Ryan, JJ & McConahey, WM 1988, 'Mortality from papillary thyroid carcinoma. A case-control study of 56 lethal cases', Cancer, vol. 62, no. 7, pp. 1381-1388.
Smith SA, Hay ID, Goellner JR, Ryan JJ, McConahey WM. Mortality from papillary thyroid carcinoma. A case-control study of 56 lethal cases. Cancer. 1988;62(7):1381-1388.
Smith, S. A. ; Hay, Ian D ; Goellner, J. R. ; Ryan, J. J. ; McConahey, W. M. / Mortality from papillary thyroid carcinoma. A case-control study of 56 lethal cases. In: Cancer. 1988 ; Vol. 62, No. 7. pp. 1381-1388.
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