Mortality and hospital utilization for hepatocellular carcinoma in the United States

W. Ray Kim, Gregory James Gores, Joanne T. Benson, Terry M Therneau, L. Joseph Melton

Research output: Contribution to journalArticle

92 Citations (Scopus)

Abstract

Background & Aims: The incidence of hepatocellular carcinoma (HCC) has been increasing in the United States. Although resource-intensive treatment modalities have been increasingly applied, these patients still have poor survival. We examined 2 nationally representative databases, the Multiple Cause of Death file and the Nationwide Inpatient Sample database, to examine trends in mortality and hospital service utilization related to HCC. Methods: In both databases, a priori criteria were used to identify cases of HCC. All other available diagnostic fields were examined to characterize coexistent liver disease. Age-, sex-, and race-specific mortality from HCC was calculated, and temporal changes in mortality rates were evaluated using the multivariable Poisson model. Hospital service utilization was estimated based on length of stay, total hospitalization charges, and principal procedures. Results: The age-, sex-, and race-specific mortality from HCC increased from 1.54 to 2.58 per 100,000 per year between 1980 and 1998. Male sex, African and Asian race, and increasing age were also associated with higher mortality. The estimated total charge for HCC hospitalizations nationwide increased from $241 million in 1988 to $509 million in 2000 after inflation adjustment. Commonly employed procedures in 2000 included angiography/embolization, resection, local ablative therapy, and liver transplantation. Conclusions: In the recent past, mortality and hospital service utilization related to HCC increased substantially. Closer epidemiologic surveillance to understand causation of HCC at the population level and to help implement primary and secondary prevention is urgently warranted.

Original languageEnglish (US)
Pages (from-to)486-493
Number of pages8
JournalGastroenterology
Volume129
Issue number2
DOIs
StatePublished - Aug 2005

Fingerprint

Hospital Mortality
Hepatocellular Carcinoma
Mortality
Databases
Hospitalization
Epidemiological Monitoring
Economic Inflation
Primary Prevention
Secondary Prevention
Causality
Liver Transplantation
Liver Diseases
Inpatients
Cause of Death
Length of Stay
Angiography
Survival
Incidence
Therapeutics
Population

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Mortality and hospital utilization for hepatocellular carcinoma in the United States. / Kim, W. Ray; Gores, Gregory James; Benson, Joanne T.; Therneau, Terry M; Melton, L. Joseph.

In: Gastroenterology, Vol. 129, No. 2, 08.2005, p. 486-493.

Research output: Contribution to journalArticle

Kim, W. Ray ; Gores, Gregory James ; Benson, Joanne T. ; Therneau, Terry M ; Melton, L. Joseph. / Mortality and hospital utilization for hepatocellular carcinoma in the United States. In: Gastroenterology. 2005 ; Vol. 129, No. 2. pp. 486-493.
@article{7a2b768306424ab7aaf80e0301f203f2,
title = "Mortality and hospital utilization for hepatocellular carcinoma in the United States",
abstract = "Background & Aims: The incidence of hepatocellular carcinoma (HCC) has been increasing in the United States. Although resource-intensive treatment modalities have been increasingly applied, these patients still have poor survival. We examined 2 nationally representative databases, the Multiple Cause of Death file and the Nationwide Inpatient Sample database, to examine trends in mortality and hospital service utilization related to HCC. Methods: In both databases, a priori criteria were used to identify cases of HCC. All other available diagnostic fields were examined to characterize coexistent liver disease. Age-, sex-, and race-specific mortality from HCC was calculated, and temporal changes in mortality rates were evaluated using the multivariable Poisson model. Hospital service utilization was estimated based on length of stay, total hospitalization charges, and principal procedures. Results: The age-, sex-, and race-specific mortality from HCC increased from 1.54 to 2.58 per 100,000 per year between 1980 and 1998. Male sex, African and Asian race, and increasing age were also associated with higher mortality. The estimated total charge for HCC hospitalizations nationwide increased from $241 million in 1988 to $509 million in 2000 after inflation adjustment. Commonly employed procedures in 2000 included angiography/embolization, resection, local ablative therapy, and liver transplantation. Conclusions: In the recent past, mortality and hospital service utilization related to HCC increased substantially. Closer epidemiologic surveillance to understand causation of HCC at the population level and to help implement primary and secondary prevention is urgently warranted.",
author = "Kim, {W. Ray} and Gores, {Gregory James} and Benson, {Joanne T.} and Therneau, {Terry M} and Melton, {L. Joseph}",
year = "2005",
month = "8",
doi = "10.1016/j.gastro.2005.05.001",
language = "English (US)",
volume = "129",
pages = "486--493",
journal = "Gastroenterology",
issn = "0016-5085",
publisher = "W.B. Saunders Ltd",
number = "2",

}

TY - JOUR

T1 - Mortality and hospital utilization for hepatocellular carcinoma in the United States

AU - Kim, W. Ray

AU - Gores, Gregory James

AU - Benson, Joanne T.

AU - Therneau, Terry M

AU - Melton, L. Joseph

PY - 2005/8

Y1 - 2005/8

N2 - Background & Aims: The incidence of hepatocellular carcinoma (HCC) has been increasing in the United States. Although resource-intensive treatment modalities have been increasingly applied, these patients still have poor survival. We examined 2 nationally representative databases, the Multiple Cause of Death file and the Nationwide Inpatient Sample database, to examine trends in mortality and hospital service utilization related to HCC. Methods: In both databases, a priori criteria were used to identify cases of HCC. All other available diagnostic fields were examined to characterize coexistent liver disease. Age-, sex-, and race-specific mortality from HCC was calculated, and temporal changes in mortality rates were evaluated using the multivariable Poisson model. Hospital service utilization was estimated based on length of stay, total hospitalization charges, and principal procedures. Results: The age-, sex-, and race-specific mortality from HCC increased from 1.54 to 2.58 per 100,000 per year between 1980 and 1998. Male sex, African and Asian race, and increasing age were also associated with higher mortality. The estimated total charge for HCC hospitalizations nationwide increased from $241 million in 1988 to $509 million in 2000 after inflation adjustment. Commonly employed procedures in 2000 included angiography/embolization, resection, local ablative therapy, and liver transplantation. Conclusions: In the recent past, mortality and hospital service utilization related to HCC increased substantially. Closer epidemiologic surveillance to understand causation of HCC at the population level and to help implement primary and secondary prevention is urgently warranted.

AB - Background & Aims: The incidence of hepatocellular carcinoma (HCC) has been increasing in the United States. Although resource-intensive treatment modalities have been increasingly applied, these patients still have poor survival. We examined 2 nationally representative databases, the Multiple Cause of Death file and the Nationwide Inpatient Sample database, to examine trends in mortality and hospital service utilization related to HCC. Methods: In both databases, a priori criteria were used to identify cases of HCC. All other available diagnostic fields were examined to characterize coexistent liver disease. Age-, sex-, and race-specific mortality from HCC was calculated, and temporal changes in mortality rates were evaluated using the multivariable Poisson model. Hospital service utilization was estimated based on length of stay, total hospitalization charges, and principal procedures. Results: The age-, sex-, and race-specific mortality from HCC increased from 1.54 to 2.58 per 100,000 per year between 1980 and 1998. Male sex, African and Asian race, and increasing age were also associated with higher mortality. The estimated total charge for HCC hospitalizations nationwide increased from $241 million in 1988 to $509 million in 2000 after inflation adjustment. Commonly employed procedures in 2000 included angiography/embolization, resection, local ablative therapy, and liver transplantation. Conclusions: In the recent past, mortality and hospital service utilization related to HCC increased substantially. Closer epidemiologic surveillance to understand causation of HCC at the population level and to help implement primary and secondary prevention is urgently warranted.

UR - http://www.scopus.com/inward/record.url?scp=23244445075&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=23244445075&partnerID=8YFLogxK

U2 - 10.1016/j.gastro.2005.05.001

DO - 10.1016/j.gastro.2005.05.001

M3 - Article

VL - 129

SP - 486

EP - 493

JO - Gastroenterology

JF - Gastroenterology

SN - 0016-5085

IS - 2

ER -