Mortality after radical cystectomy

Impact of obesity versus adiposity after adjusting for skeletal muscle wasting

Sarah P. Psutka, Stephen A. Boorjian, Michael R. Moynagh, Grant D. Schmit, Igor Frank, Alonso Carrasco, Suzanne B. Stewart, Robert Tarrell, Prabin Thapa, Matthew K. Tollefson

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Abstract

Purpose We assess the impact of obesity, as measured conventionally by body mass index vs excess adiposity as measured by fat mass index, on mortality after radical cystectomy for bladder cancer, adjusting for the presence of skeletal muscle wasting. Materials and Methods This retrospective cohort study included 262 patients treated with radical cystectomy for bladder cancer between 2000 and 2008 at the Mayo Clinic. Lumbar skeletal muscle and adipose compartment areas were measured on preoperative imaging. Overall survival was compared according to gender specific consensus fat mass index and skeletal muscle index thresholds as well as conventional body mass index based criteria. Predictors of all cause mortality were assessed by multivariable modeling. Results Increasing body mass index correlated with improved overall survival (p=0.03) while fat mass index based obesity did not (p=0.08). After stratification by sarcopenia, no obesity related 5-year overall survival benefit was observed (68% vs 51.4%, p=0.2 obese vs normal and 40% vs 37.4%, p=0.7 sarcopenia vs sarcopenic/obese). On multivariable analysis class I obesity according to body mass index (HR 0.79, p=0.33) or fat mass index criteria (HR 0.85, p=0.45) was not independently associated with all cause mortality after adjusting for sarcopenia (HR 1.7, p=0.01) as well as age, performance status, pTN stage and smoking status. However, in patients with normal lean muscle mass each 1 kg/m<sup>2</sup> increase in weight or adipose mass was associated with a 7% to 14% decrease in all cause mortality. Conclusions After adjusting for lean muscle wasting, neither measurements of obesity nor adiposity were significantly associated with all cause mortality in patients treated with radical cystectomy, although subanalyses suggest a potential benefit among those with normal lean muscle mass.

Original languageEnglish (US)
Pages (from-to)1507-1513
Number of pages7
JournalJournal of Urology
Volume193
Issue number5
DOIs
StatePublished - May 1 2015

Fingerprint

Cystectomy
Adiposity
Sarcopenia
Skeletal Muscle
Obesity
Body Mass Index
Fats
Mortality
Urinary Bladder Neoplasms
Muscles
Survival
Cohort Studies
Retrospective Studies
Smoking
Weights and Measures

Keywords

  • body mass index
  • cystectomy
  • mortality
  • obesity
  • sarcopenia

ASJC Scopus subject areas

  • Urology

Cite this

Psutka, S. P., Boorjian, S. A., Moynagh, M. R., Schmit, G. D., Frank, I., Carrasco, A., ... Tollefson, M. K. (2015). Mortality after radical cystectomy: Impact of obesity versus adiposity after adjusting for skeletal muscle wasting. Journal of Urology, 193(5), 1507-1513. https://doi.org/10.1016/j.juro.2014.11.088

Mortality after radical cystectomy : Impact of obesity versus adiposity after adjusting for skeletal muscle wasting. / Psutka, Sarah P.; Boorjian, Stephen A.; Moynagh, Michael R.; Schmit, Grant D.; Frank, Igor; Carrasco, Alonso; Stewart, Suzanne B.; Tarrell, Robert; Thapa, Prabin; Tollefson, Matthew K.

In: Journal of Urology, Vol. 193, No. 5, 01.05.2015, p. 1507-1513.

Research output: Contribution to journalArticle

Psutka, SP, Boorjian, SA, Moynagh, MR, Schmit, GD, Frank, I, Carrasco, A, Stewart, SB, Tarrell, R, Thapa, P & Tollefson, MK 2015, 'Mortality after radical cystectomy: Impact of obesity versus adiposity after adjusting for skeletal muscle wasting', Journal of Urology, vol. 193, no. 5, pp. 1507-1513. https://doi.org/10.1016/j.juro.2014.11.088
Psutka, Sarah P. ; Boorjian, Stephen A. ; Moynagh, Michael R. ; Schmit, Grant D. ; Frank, Igor ; Carrasco, Alonso ; Stewart, Suzanne B. ; Tarrell, Robert ; Thapa, Prabin ; Tollefson, Matthew K. / Mortality after radical cystectomy : Impact of obesity versus adiposity after adjusting for skeletal muscle wasting. In: Journal of Urology. 2015 ; Vol. 193, No. 5. pp. 1507-1513.
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abstract = "Purpose We assess the impact of obesity, as measured conventionally by body mass index vs excess adiposity as measured by fat mass index, on mortality after radical cystectomy for bladder cancer, adjusting for the presence of skeletal muscle wasting. Materials and Methods This retrospective cohort study included 262 patients treated with radical cystectomy for bladder cancer between 2000 and 2008 at the Mayo Clinic. Lumbar skeletal muscle and adipose compartment areas were measured on preoperative imaging. Overall survival was compared according to gender specific consensus fat mass index and skeletal muscle index thresholds as well as conventional body mass index based criteria. Predictors of all cause mortality were assessed by multivariable modeling. Results Increasing body mass index correlated with improved overall survival (p=0.03) while fat mass index based obesity did not (p=0.08). After stratification by sarcopenia, no obesity related 5-year overall survival benefit was observed (68{\%} vs 51.4{\%}, p=0.2 obese vs normal and 40{\%} vs 37.4{\%}, p=0.7 sarcopenia vs sarcopenic/obese). On multivariable analysis class I obesity according to body mass index (HR 0.79, p=0.33) or fat mass index criteria (HR 0.85, p=0.45) was not independently associated with all cause mortality after adjusting for sarcopenia (HR 1.7, p=0.01) as well as age, performance status, pTN stage and smoking status. However, in patients with normal lean muscle mass each 1 kg/m2 increase in weight or adipose mass was associated with a 7{\%} to 14{\%} decrease in all cause mortality. Conclusions After adjusting for lean muscle wasting, neither measurements of obesity nor adiposity were significantly associated with all cause mortality in patients treated with radical cystectomy, although subanalyses suggest a potential benefit among those with normal lean muscle mass.",
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AB - Purpose We assess the impact of obesity, as measured conventionally by body mass index vs excess adiposity as measured by fat mass index, on mortality after radical cystectomy for bladder cancer, adjusting for the presence of skeletal muscle wasting. Materials and Methods This retrospective cohort study included 262 patients treated with radical cystectomy for bladder cancer between 2000 and 2008 at the Mayo Clinic. Lumbar skeletal muscle and adipose compartment areas were measured on preoperative imaging. Overall survival was compared according to gender specific consensus fat mass index and skeletal muscle index thresholds as well as conventional body mass index based criteria. Predictors of all cause mortality were assessed by multivariable modeling. Results Increasing body mass index correlated with improved overall survival (p=0.03) while fat mass index based obesity did not (p=0.08). After stratification by sarcopenia, no obesity related 5-year overall survival benefit was observed (68% vs 51.4%, p=0.2 obese vs normal and 40% vs 37.4%, p=0.7 sarcopenia vs sarcopenic/obese). On multivariable analysis class I obesity according to body mass index (HR 0.79, p=0.33) or fat mass index criteria (HR 0.85, p=0.45) was not independently associated with all cause mortality after adjusting for sarcopenia (HR 1.7, p=0.01) as well as age, performance status, pTN stage and smoking status. However, in patients with normal lean muscle mass each 1 kg/m2 increase in weight or adipose mass was associated with a 7% to 14% decrease in all cause mortality. Conclusions After adjusting for lean muscle wasting, neither measurements of obesity nor adiposity were significantly associated with all cause mortality in patients treated with radical cystectomy, although subanalyses suggest a potential benefit among those with normal lean muscle mass.

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