Morphometric alteration of rat myelinated fibers with aging

G. A. Knox, E. Kokmen, Peter J Dyck

Research output: Contribution to journalArticle

101 Citations (Scopus)

Abstract

The number, size, density and pathologic alterations of myelinated fibers (MF) of ventral and dorsal roots of peroneal and sural nerves in groups of female Fischer 344 rats at 10, 20, and 30 months of age were evaluated to characterize nerve changes with old age. Except for minimal changes in the peroneal nerve, no statistically significant alteration in number of MF/nerve or in the fascicular area was associated with aging. The unaltered number was misleading since striking changes in MF size distribution, pathologic alterations of fibers and the presence of regeneration clusters suggested age-related degenerative and regenerative events. These changes were most dramatic in the ventral root, where myelin infolding, myelin separation from axon and ballooning, macrophagia and hyperplasia of Schwann cell nuclei were pronounced. Concomitant with these alterations, axonal atrophy (a reduction in caliber of axons relative to myelin spiral length or number of myelin lamellae) was demonstrated in MF of the ventral root in old age.

Original languageEnglish (US)
Pages (from-to)119-139
Number of pages21
JournalJournal of Neuropathology and Experimental Neurology
Volume48
Issue number2
StatePublished - 1989

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Spinal Nerve Roots
Myelin Sheath
Peroneal Nerve
Axons
Myelinated Nerve Fibers
Sural Nerve
Schwann Cells
Inbred F344 Rats
Cell Nucleus
Atrophy
Hyperplasia
Regeneration

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Neuroscience(all)

Cite this

Morphometric alteration of rat myelinated fibers with aging. / Knox, G. A.; Kokmen, E.; Dyck, Peter J.

In: Journal of Neuropathology and Experimental Neurology, Vol. 48, No. 2, 1989, p. 119-139.

Research output: Contribution to journalArticle

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