Morphological evidence for an invasion-independent metastasis pathway exists in multiple human cancers

Takashi Sugino, Tomiko Yamaguchi, Go Ogura, Atsuko Saito, Takeaki Hashimoto, Nobuo Hoshi, Sakaya Yoshida, Steven Goodison, Toshimitsu Suzuki

Research output: Contribution to journalArticle

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Abstract

Background: We have previously described an alternative invasion-independent pathway of cancer metastasis in a murine mammary tumor model. This pathway is initiated by intravasation of tumor nests enveloped by endothelial cells of sinusoidal vasculature within the tumor. In this study, we examined whether evidence for the invasion-independent pathway of metastasis is present in human cancers. Methods: Archival specimens of 10 common types of human cancers were examined for the presence of sinusoidal vasculature enveloping tumor nests and subsequently generated endothelial-covered tumor emboli in efferent veins. Results: A percentage of tumor emboli in all cancers was found to be enveloped by endothelial cells, but these structures were particularly prevalent in renal cell carcinomas, hepatocellular carcinomas and follicular thyroid carcinomas. A common feature of the vasculature in these tumors was the presence of dilated sinusoid-like structures surrounding tumor nests. A high mean vascular area within tumors, an indication of sinusoidal vascular development, was significantly related to the presence of endothelial-covered tumor emboli. Conclusions: These results suggest that an invasion-independent metastatic pathway is possible in a wide variety of human cancers. Further investigation of this phenomenon may present new therapeutic strategies for the amelioration of cancer metastasis.

Original languageEnglish (US)
Article number9
JournalBMC Medicine
Volume2
DOIs
StatePublished - Apr 5 2004
Externally publishedYes

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Neoplasm Metastasis
Neoplasms
Embolism
Blood Vessels
Endothelial Cells
Follicular Adenocarcinoma
Renal Cell Carcinoma
Hepatocellular Carcinoma
Veins
Breast Neoplasms

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Sugino, T., Yamaguchi, T., Ogura, G., Saito, A., Hashimoto, T., Hoshi, N., ... Suzuki, T. (2004). Morphological evidence for an invasion-independent metastasis pathway exists in multiple human cancers. BMC Medicine, 2, [9]. https://doi.org/10.1186/1741-7015-2-9

Morphological evidence for an invasion-independent metastasis pathway exists in multiple human cancers. / Sugino, Takashi; Yamaguchi, Tomiko; Ogura, Go; Saito, Atsuko; Hashimoto, Takeaki; Hoshi, Nobuo; Yoshida, Sakaya; Goodison, Steven; Suzuki, Toshimitsu.

In: BMC Medicine, Vol. 2, 9, 05.04.2004.

Research output: Contribution to journalArticle

Sugino, T, Yamaguchi, T, Ogura, G, Saito, A, Hashimoto, T, Hoshi, N, Yoshida, S, Goodison, S & Suzuki, T 2004, 'Morphological evidence for an invasion-independent metastasis pathway exists in multiple human cancers', BMC Medicine, vol. 2, 9. https://doi.org/10.1186/1741-7015-2-9
Sugino, Takashi ; Yamaguchi, Tomiko ; Ogura, Go ; Saito, Atsuko ; Hashimoto, Takeaki ; Hoshi, Nobuo ; Yoshida, Sakaya ; Goodison, Steven ; Suzuki, Toshimitsu. / Morphological evidence for an invasion-independent metastasis pathway exists in multiple human cancers. In: BMC Medicine. 2004 ; Vol. 2.
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