Morphine initiates migrating myoelectric complexes by acting on peripheral opioid receptors

G. L. Telford, M. Hoshmonai, A. J. Moses, J. H. Szurszewski

Research output: Contribution to journalArticle

23 Scopus citations

Abstract

The role of peripheral and central opioid receptors in morphine-induced migrating myoelectric complexes (MMECs) was studied in conscious dogs implanted with silver-silver chloride electrodes. In normal fasted dogs morphine (100-200 μg/kg iv) initiated phase III of the MMEC in the duodenum. Once initiated the MMEC propagated distally. This effect of morphine was blocked by the opioid receptor antagonists naloxone (2 mg/kg iv) and N,N-diallylnormorphinium bromide (4 mg/kg iv). Higher doses of morphine (300-600 μg/kg iv) initiated phase III activity in fed dogs as early as 20 min after feeding, while lower doses (150 μg/kg iv) initiated phase III activity routinely when administered 100 min after feeding. In dogs with bilateral vagotomies and bilateral thoracolumbar sympathetic chain ganglionectomies, morphine (150 μg/kg iv) initiated phase III activity in the duodenum, which then migrated distally. This study demonstrates that morphine initiates phase III of the MMEC by acting through peripheral opioid receptors.

Original languageEnglish (US)
Pages (from-to)G557-G562
JournalAmerican Journal of Physiology - Gastrointestinal and Liver Physiology
Volume12
Issue number5
DOIs
StatePublished - Jan 1 1985

ASJC Scopus subject areas

  • Physiology
  • Hepatology
  • Gastroenterology
  • Physiology (medical)

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