More thoughts on plaques and tangles

Shu Hui Yen

doi:10.1016/0197-4580(86)90056-4

More thoughts on plaques and tangles

Shu Hui Yen

Neuroscience

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

Alzheimer neurofibrillary tangles (NFT) contain unique antigenic determinants and determinants in common with several normal cytoskeletal proteins which include the high molecular weight neurofilament proteins, microtubule associated proteins and vimentin. The unique determinants are found in nearly all NFT whereas the determinants in common with normal cytoskeletal proteins are generally detected only in a fraction of NFT. It remains to be determined whether a particular type of cytoskeletal protein is more involved than others in the formation of NFT and if posttranslational modification of certain normal proteins is responsible for the expression of unique antigenic determinants.

Original language	English (US)
Pages (from-to)	432-434
Number of pages	3
Journal	Neurobiology of aging
Volume	7
Issue number	6
DOIs	https://doi.org/10.1016/0197-4580(86)90056-4
State	Published - 1986

ASJC Scopus subject areas

Clinical Neurology
Geriatrics and Gerontology
Aging
General Neuroscience
Developmental Biology

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abstract = "Alzheimer neurofibrillary tangles (NFT) contain unique antigenic determinants and determinants in common with several normal cytoskeletal proteins which include the high molecular weight neurofilament proteins, microtubule associated proteins and vimentin. The unique determinants are found in nearly all NFT whereas the determinants in common with normal cytoskeletal proteins are generally detected only in a fraction of NFT. It remains to be determined whether a particular type of cytoskeletal protein is more involved than others in the formation of NFT and if posttranslational modification of certain normal proteins is responsible for the expression of unique antigenic determinants.",

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AB - Alzheimer neurofibrillary tangles (NFT) contain unique antigenic determinants and determinants in common with several normal cytoskeletal proteins which include the high molecular weight neurofilament proteins, microtubule associated proteins and vimentin. The unique determinants are found in nearly all NFT whereas the determinants in common with normal cytoskeletal proteins are generally detected only in a fraction of NFT. It remains to be determined whether a particular type of cytoskeletal protein is more involved than others in the formation of NFT and if posttranslational modification of certain normal proteins is responsible for the expression of unique antigenic determinants.

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More thoughts on plaques and tangles

Abstract

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