Morbidity and mortality in patients with posterior circulation aneurysms treated with the pipeline embolization device: A subgroup analysis of the international retrospective study of the pipeline embolization device

Demetrius K. Lopes, Dong Kyu Jang, Saruhan Cekirge, David Fiorella, Ricardo A. Hanel, David F Kallmes, Elad I. Levy, Pedro Lylyk

Research output: Contribution to journalArticlepeer-review

14 Scopus citations

Abstract

Background: The safety of PipelineTM Embolization Device (PED;Medtronic Inc, Dublin, Ireland) in posterior circulation aneurysms is still controversial. Objective: To study complications associated with the treatment of posterior circulation aneurysms by conducting a subgroup analysis from the International Retrospective Study of PED registry. Methods: Data from 91 consecutive patients with 95 posterior circulation aneurysms at 17 centers between July 2008 to February 2013 were analyzed. The primary endpoint was defined as any complication leading to neurological morbidity or death. The outcome predictors were calculated using Kaplan.Meier and Cox regression methods. Results: The mean aneurysm size was 13.8 mm. Aneurysm types were saccular (36.8%), fusiform (29.5%), dissecting (28.4%), and others (5.3%). The median follow-up was 21.1 mo. Twelve (13.2%) patients encountered a primary endpoint event. In multivariate analysis for the primary endpoint, use of ≥3 PEDs and fusiform shape compared with other shapes had hazard ratios (HRs) of 7.77 (95% confidence interval [CI], 2.48-25.86; P=.0007) and 3.48 (95% CI, 1.06-13.39; P=.0488), respectively. Themultivariate HR of aneurysmsize for neurological morbidity after PED implantation was 1.11 (95% CI, 1.04-1.18; P = .0015), and HRs of ruptured aneurysm and age for neurologicalmortality were 8.1 (95% CI, 1.31-41.26; P = .0197) and 1.07 (95% CI, 1.02-1.15; P = .0262), respectively. Basilar artery aneurysm had an HR of 3.54 (95% CI, 1.12-14.18, P = .0529) in the univariate analysis for major outcomes. Conclusion: PED implantation may be considered for the treatment of posterior circulation aneurysms, especially of saccular or dissecting type. Ourmajor complications appear to be comparable to those reported previously after clipping and coiling in the literature. Neurointerventionists should consider the shape, size, rupture, and location of complex posterior circulation aneurysms aswell as age and PED number before the PED placement.

Original languageEnglish (US)
Pages (from-to)488-500
Number of pages13
JournalClinical Neurosurgery
Volume83
Issue number3
DOIs
StatePublished - Jan 1 2018

Keywords

  • Aneurysm
  • Complications
  • Fusiform
  • Pipeline
  • Posterior circulation

ASJC Scopus subject areas

  • Surgery
  • Clinical Neurology

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