Abstract
Background: Patients with cirrhosis have a reduced life expectancy. Anesthesia and surgery have been associated with clinical decompensation in patients with cirrhosis. Methods: The authors retrospectively reviewed the records of all patients with the diagnosis of cirrhosis who underwent any surgical procedure under anesthesia at their institution between January 1980 and January 1991 (n = 733). Univariate and multivariate analyses were used to identify the variables associated with perioperative complications and short- and long-term survival. Results: The perioperative mortality rate (within 30 days of surgery) was 11.6%. The perioperative complication rate was 30.1%. Postoperative pneumonia was the most frequent complication. Multivariate factors that were associated with perioperative complications and mortality included male gender, a high Child-Pugh score, the presence of ascites, a diagnosis of cirrhosis other than primary biliary cirrhosis (especially cryptogenic cirrhosis), an elevated creatinine concentration, the diagnosis of chronic obstructive pulmonary disease, preoperative infection, preoperative upper gastrointestinal bleeding, a high American Society of Anesthesiologists physical status rating, a high surgical severity score, surgery on the respiratory system, and the presence of intraoperative hypotension. Conclusion: Risk factors have been identified for patients with cirrhosis who undergo anesthesia and surgery.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 42-53 |
| Number of pages | 12 |
| Journal | Anesthesiology |
| Volume | 90 |
| Issue number | 1 |
| State | Published - Jan 1999 |
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Keywords
- Liver disease
- Perioperative complications
- Risk factors
ASJC Scopus subject areas
- Anesthesiology and Pain Medicine
Cite this
Morbidity and mortality in cirrhotic patients undergoing anesthesia and surgery. / Ziser, Avishai; Plevak, David J.; Wiesner, Russell H.; Rakela, Jorge; Offord, Kenneth P.; Brown, David L.
In: Anesthesiology, Vol. 90, No. 1, 01.1999, p. 42-53.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Morbidity and mortality in cirrhotic patients undergoing anesthesia and surgery
AU - Ziser, Avishai
AU - Plevak, David J.
AU - Wiesner, Russell H.
AU - Rakela, Jorge
AU - Offord, Kenneth P.
AU - Brown, David L.
PY - 1999/1
Y1 - 1999/1
N2 - Background: Patients with cirrhosis have a reduced life expectancy. Anesthesia and surgery have been associated with clinical decompensation in patients with cirrhosis. Methods: The authors retrospectively reviewed the records of all patients with the diagnosis of cirrhosis who underwent any surgical procedure under anesthesia at their institution between January 1980 and January 1991 (n = 733). Univariate and multivariate analyses were used to identify the variables associated with perioperative complications and short- and long-term survival. Results: The perioperative mortality rate (within 30 days of surgery) was 11.6%. The perioperative complication rate was 30.1%. Postoperative pneumonia was the most frequent complication. Multivariate factors that were associated with perioperative complications and mortality included male gender, a high Child-Pugh score, the presence of ascites, a diagnosis of cirrhosis other than primary biliary cirrhosis (especially cryptogenic cirrhosis), an elevated creatinine concentration, the diagnosis of chronic obstructive pulmonary disease, preoperative infection, preoperative upper gastrointestinal bleeding, a high American Society of Anesthesiologists physical status rating, a high surgical severity score, surgery on the respiratory system, and the presence of intraoperative hypotension. Conclusion: Risk factors have been identified for patients with cirrhosis who undergo anesthesia and surgery.
AB - Background: Patients with cirrhosis have a reduced life expectancy. Anesthesia and surgery have been associated with clinical decompensation in patients with cirrhosis. Methods: The authors retrospectively reviewed the records of all patients with the diagnosis of cirrhosis who underwent any surgical procedure under anesthesia at their institution between January 1980 and January 1991 (n = 733). Univariate and multivariate analyses were used to identify the variables associated with perioperative complications and short- and long-term survival. Results: The perioperative mortality rate (within 30 days of surgery) was 11.6%. The perioperative complication rate was 30.1%. Postoperative pneumonia was the most frequent complication. Multivariate factors that were associated with perioperative complications and mortality included male gender, a high Child-Pugh score, the presence of ascites, a diagnosis of cirrhosis other than primary biliary cirrhosis (especially cryptogenic cirrhosis), an elevated creatinine concentration, the diagnosis of chronic obstructive pulmonary disease, preoperative infection, preoperative upper gastrointestinal bleeding, a high American Society of Anesthesiologists physical status rating, a high surgical severity score, surgery on the respiratory system, and the presence of intraoperative hypotension. Conclusion: Risk factors have been identified for patients with cirrhosis who undergo anesthesia and surgery.
KW - Liver disease
KW - Perioperative complications
KW - Risk factors
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UR - http://www.scopus.com/inward/citedby.url?scp=0032615002&partnerID=8YFLogxK
M3 - Article
C2 - 9915311
AN - SCOPUS:0032615002
VL - 90
SP - 42
EP - 53
JO - Anesthesiology
JF - Anesthesiology
SN - 0003-3022
IS - 1
ER -