Abstract
We recently developed a modified Dupriez prognostic scoring system (PSS) that effectively discriminated between high-, intermediate-, and low-risk young patients (age ≤60 years) with primary myelofibrosis (PMF) based on the respective presence of none, one, or two or more of the following parameters: hemoglobin <10 g/dL, leukocyte count <4 or >30 × 109 L-1, and platelet count <100 × 109 L-1. The current study (n = 129; median age, 52 years; 69 males) reveals, on multivariable analysis, that an absolute monocyte count of ≥1 × 109 L-1 carries an independent predictive value (p = 0.02), for an inferior survival, in addition to that provided by hemoglobin level (p = 0.002), platelet count (0.02), and leukocyte count (p = 0.16). The inclusion of the monocyte count as a fourth risk factor enabled the construction of a new and improved Mayo PSS; median survival was 173, 61, and 26 months in the absence of all four (low-risk), three (intermediate-risk), or two or less (high-risk) adverse features, respectively (p < 0.0001). The independent prognostic value of monocytosis was validated in a separate database of 97 patients with PMF from another institution.
Original language | English (US) |
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Pages (from-to) | 1503-1509 |
Number of pages | 7 |
Journal | Leukemia Research |
Volume | 31 |
Issue number | 11 |
DOIs | |
State | Published - Nov 2007 |
Keywords
- Monocytosis
- Myelofibrosis
- Myeloproliferative disorder
- Prognosis
- Survival
ASJC Scopus subject areas
- Hematology
- Oncology
- Cancer Research