TY - JOUR
T1 - Monocular Oral Reading Performance After Amblyopia Treatment in Children
AU - Repka, Michael X.
AU - Kraker, Raymond T.
AU - Beck, Roy W.
AU - Cotter, Susan A.
AU - Holmes, Jonathan M.
AU - Arnold, Robert W.
AU - Astle, William F.
AU - Sala, Nicholas A.
AU - Tien, D. Robbins
N1 - Funding Information:
This study was supported through Cooperative Agreement EY011751 with the National Eye Institute of the National Institutes of Health, Bethesda, Maryland, Department of Health and Human Services, and was conducted by the Pediatric Eye Disease Investigator Group at seven of the initial 47 participating clinical sites. The authors indicate no financial conflict of interest. Involved in the design of study (M.X.R., R.T.K., R.W.B. S.A.C., J. M.H., R.W.A); collection, management, analysis, and interpretation of the data (M.X.R., R.T.K., R.W.B. S.A.C., J.M.H., R.W.A, W.F.A., N.A.S., D.R.T.); and preparation, review, and final approval of the manuscript (M.X.R., R.T. K., R.W.B. S.A.C., J.M.H., R.W.A, W.F.A., N.A.S., D.R.T.). The respective Institutional Review Boards approved the protocol and Health Insurance Portability and Accountability Act-compliant informed consent forms. The protocol and informed consent forms were approved by the institutional review boards for each of the named authors, and the parent of each study patient gave written informed consent. Study oversight was provided by an independent data and safety monitoring committee. The study is registered at www.clinicaltrials.gov (Registration no.: NCT00000170 ) and the trial registry name is Amblyopia Treatment Study: Occlusion vs Pharmacologic Therapy for Moderate Amblyopia. The Wilmer Institute and the Mayo Clinic centers received support used for this project from an unrestricted Grant from Research to Prevent Blindness Inc, New York, New York.
PY - 2008/12
Y1 - 2008/12
N2 - Purpose: To evaluate the monocular oral reading rate, accuracy, fluency, and comprehension in 10-year-old children previously treated for amblyopia. Design: Prospective, observational case series. Methods: Seventy-nine children (mean age, 10.3 years) previously treated in a multicenter randomized trial comparing patching and atropine were tested at seven sites using a modification of the Gray Oral Reading Test, Fourth Edition (GORT-4). Results: The mean visual acuities (VA) in the amblyopic and fellow eyes at the time of the reading assessment were 0.17 logarithm of the minimum angle of resolution (logMAR) units (approximately 20/32) and -0.03 logMAR units (approximately 20/20), respectively. Compared with the sound eye, amblyopic eye performance was worse when reading orally with respect to rate (P < .001), accuracy (P = .03), and fluency (P < .001). Reading comprehension scores were similar with the amblyopic and fellow eyes (P = .45). Similar results were found with respect to original treatment group assignment (atropine or patching). There was a modest correlation between interocular difference (IOD) of VA at age 10 years and IOD in reading rate (r = 0.37; 95% confidence interval [CI], 0.18 to 0.56) and fluency (r = 0.28; 95% CI, 0.08 to 0.49). There was no correlation between the IOD in VA and IOD in accuracy (r = 0.08; 95% CI, -0.14 to 0.30) or comprehension (r = 0.16; 95% CI, -0.05 to 0.37). Conclusions: The monocular oral reading ability when measured with the GORT-4 was slightly worse when reading with previously treated amblyopic eyes compared with fellow eyes in terms of rate, accuracy, and fluency, but reading comprehension testing was similar.
AB - Purpose: To evaluate the monocular oral reading rate, accuracy, fluency, and comprehension in 10-year-old children previously treated for amblyopia. Design: Prospective, observational case series. Methods: Seventy-nine children (mean age, 10.3 years) previously treated in a multicenter randomized trial comparing patching and atropine were tested at seven sites using a modification of the Gray Oral Reading Test, Fourth Edition (GORT-4). Results: The mean visual acuities (VA) in the amblyopic and fellow eyes at the time of the reading assessment were 0.17 logarithm of the minimum angle of resolution (logMAR) units (approximately 20/32) and -0.03 logMAR units (approximately 20/20), respectively. Compared with the sound eye, amblyopic eye performance was worse when reading orally with respect to rate (P < .001), accuracy (P = .03), and fluency (P < .001). Reading comprehension scores were similar with the amblyopic and fellow eyes (P = .45). Similar results were found with respect to original treatment group assignment (atropine or patching). There was a modest correlation between interocular difference (IOD) of VA at age 10 years and IOD in reading rate (r = 0.37; 95% confidence interval [CI], 0.18 to 0.56) and fluency (r = 0.28; 95% CI, 0.08 to 0.49). There was no correlation between the IOD in VA and IOD in accuracy (r = 0.08; 95% CI, -0.14 to 0.30) or comprehension (r = 0.16; 95% CI, -0.05 to 0.37). Conclusions: The monocular oral reading ability when measured with the GORT-4 was slightly worse when reading with previously treated amblyopic eyes compared with fellow eyes in terms of rate, accuracy, and fluency, but reading comprehension testing was similar.
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U2 - 10.1016/j.ajo.2008.06.022
DO - 10.1016/j.ajo.2008.06.022
M3 - Article
C2 - 18708179
AN - SCOPUS:56249102749
SN - 0002-9394
VL - 146
SP - 942
EP - 947
JO - American journal of ophthalmology
JF - American journal of ophthalmology
IS - 6
ER -