Monoclonal gammopathy of undetermined significance, Waldenström macroglobulinemia, AL amyloidosis, and related plasma cell disorders

Diagnosis and treatment

Research output: Contribution to journalArticle

139 Citations (Scopus)

Abstract

The spectrum of plasma cell disorders is broad. Monoclonal gammopathy of undetermined significance and smoldering multiple myeloma are asymptomatic disorders characterized by monoclonal plasma cell proliferation in the bone marrow in the absence of end-organ damage. Waldenström macroglobulinemia typically involves an ontogenically less mature lymphoplasmacytic bone marrow cell and is characterized by secretion of a monoclonal IgM protein. Solitary plasmacytoma is the only known potentially curable plasma cell disorder. Finally, AL (Immunoglobulin light chain) amyloidosis and POEMS (polyneuropathy, organomegaly, endocrinopathy, monoclonal gammopathy, and skin changes) syndrome are disorders characterized by low tumor burden but profound multisystemic disease. Updated diagnostic criteria for these disorders, risk stratification models to determine prognosis, and the current management of these diverse entities are discussed in this review.

Original languageEnglish (US)
Pages (from-to)693-703
Number of pages11
JournalMayo Clinic Proceedings
Volume81
Issue number5
DOIs
StatePublished - 2006

Fingerprint

Monoclonal Gammopathy of Undetermined Significance
Waldenstrom Macroglobulinemia
Amyloidosis
Plasma Cells
POEMS Syndrome
Immunoglobulin Light Chains
Paraproteinemias
Plasmacytoma
Tumor Burden
Multiple Myeloma
Bone Marrow Cells
Immunoglobulin M
Therapeutics
Bone Marrow
Cell Proliferation
Skin
Proteins

ASJC Scopus subject areas

  • Medicine(all)

Cite this

@article{dec7b70ae38443538787a0df38b29674,
title = "Monoclonal gammopathy of undetermined significance, Waldenstr{\"o}m macroglobulinemia, AL amyloidosis, and related plasma cell disorders: Diagnosis and treatment",
abstract = "The spectrum of plasma cell disorders is broad. Monoclonal gammopathy of undetermined significance and smoldering multiple myeloma are asymptomatic disorders characterized by monoclonal plasma cell proliferation in the bone marrow in the absence of end-organ damage. Waldenstr{\"o}m macroglobulinemia typically involves an ontogenically less mature lymphoplasmacytic bone marrow cell and is characterized by secretion of a monoclonal IgM protein. Solitary plasmacytoma is the only known potentially curable plasma cell disorder. Finally, AL (Immunoglobulin light chain) amyloidosis and POEMS (polyneuropathy, organomegaly, endocrinopathy, monoclonal gammopathy, and skin changes) syndrome are disorders characterized by low tumor burden but profound multisystemic disease. Updated diagnostic criteria for these disorders, risk stratification models to determine prognosis, and the current management of these diverse entities are discussed in this review.",
author = "Rajkumar, {S Vincent} and Angela Dispenzieri and Kyle, {Robert A.}",
year = "2006",
doi = "10.4065/81.5.693",
language = "English (US)",
volume = "81",
pages = "693--703",
journal = "Mayo Clinic Proceedings",
issn = "0025-6196",
publisher = "Elsevier Science",
number = "5",

}

TY - JOUR

T1 - Monoclonal gammopathy of undetermined significance, Waldenström macroglobulinemia, AL amyloidosis, and related plasma cell disorders

T2 - Diagnosis and treatment

AU - Rajkumar, S Vincent

AU - Dispenzieri, Angela

AU - Kyle, Robert A.

PY - 2006

Y1 - 2006

N2 - The spectrum of plasma cell disorders is broad. Monoclonal gammopathy of undetermined significance and smoldering multiple myeloma are asymptomatic disorders characterized by monoclonal plasma cell proliferation in the bone marrow in the absence of end-organ damage. Waldenström macroglobulinemia typically involves an ontogenically less mature lymphoplasmacytic bone marrow cell and is characterized by secretion of a monoclonal IgM protein. Solitary plasmacytoma is the only known potentially curable plasma cell disorder. Finally, AL (Immunoglobulin light chain) amyloidosis and POEMS (polyneuropathy, organomegaly, endocrinopathy, monoclonal gammopathy, and skin changes) syndrome are disorders characterized by low tumor burden but profound multisystemic disease. Updated diagnostic criteria for these disorders, risk stratification models to determine prognosis, and the current management of these diverse entities are discussed in this review.

AB - The spectrum of plasma cell disorders is broad. Monoclonal gammopathy of undetermined significance and smoldering multiple myeloma are asymptomatic disorders characterized by monoclonal plasma cell proliferation in the bone marrow in the absence of end-organ damage. Waldenström macroglobulinemia typically involves an ontogenically less mature lymphoplasmacytic bone marrow cell and is characterized by secretion of a monoclonal IgM protein. Solitary plasmacytoma is the only known potentially curable plasma cell disorder. Finally, AL (Immunoglobulin light chain) amyloidosis and POEMS (polyneuropathy, organomegaly, endocrinopathy, monoclonal gammopathy, and skin changes) syndrome are disorders characterized by low tumor burden but profound multisystemic disease. Updated diagnostic criteria for these disorders, risk stratification models to determine prognosis, and the current management of these diverse entities are discussed in this review.

UR - http://www.scopus.com/inward/record.url?scp=33646408531&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33646408531&partnerID=8YFLogxK

U2 - 10.4065/81.5.693

DO - 10.4065/81.5.693

M3 - Article

VL - 81

SP - 693

EP - 703

JO - Mayo Clinic Proceedings

JF - Mayo Clinic Proceedings

SN - 0025-6196

IS - 5

ER -