TY - JOUR
T1 - Monoclonal gammopathy of undetermined significance
T2 - A consensus statement: Guideline
AU - Berenson, James R.
AU - Anderson, Kenneth C.
AU - Audell, Robert A.
AU - Boccia, Ralph V.
AU - Coleman, Morton
AU - Dimopoulos, Meletios A.
AU - Drake, Matthew T.
AU - Fonseca, Rafael
AU - Harousseau, Jean Luc
AU - Joshua, Douglas
AU - Lonial, Sagar
AU - Niesvizky, Ruben
AU - Palumbo, Antonio
AU - Roodman, G. David
AU - San-Miguel, Jesus F.
AU - Singhal, Seema
AU - Weber, Donna M.
AU - Zangari, Maurizio
AU - Wirtschafter, Eric
AU - Yellin, Ori
AU - Kyle, Robert A.
PY - 2010/7
Y1 - 2010/7
N2 - On February 25, 2009, a panel of international experts on plasma cell dyscrasia and skeletal disease met to discuss monoclonal gammopathy of undetermined significance (MGUS). This non-malignant B-cell disorder is the most common plasma cell dyscrasia and is associated with an increased risk of developing serious B-cell disorders. Individuals with MGUS also have an increased risk of osteoporosis and osteopenia associated with an increased likelihood of developing fractures especially in the vertebral column, peripheral neuropathy and thromboembolic events. The goal of the meeting was to develop a consensus statement regarding the appropriate tests to screen, evaluate and follow-up patients with MGUS. The panel also addressed the identification and treatment of MGUS-related skeletal problems, thromboembolic events and neurological complications. The following consensus statement outlines the conclusions and marks the first time that a consensus statement for the screening and treatment of MGUS has been clearly stated.
AB - On February 25, 2009, a panel of international experts on plasma cell dyscrasia and skeletal disease met to discuss monoclonal gammopathy of undetermined significance (MGUS). This non-malignant B-cell disorder is the most common plasma cell dyscrasia and is associated with an increased risk of developing serious B-cell disorders. Individuals with MGUS also have an increased risk of osteoporosis and osteopenia associated with an increased likelihood of developing fractures especially in the vertebral column, peripheral neuropathy and thromboembolic events. The goal of the meeting was to develop a consensus statement regarding the appropriate tests to screen, evaluate and follow-up patients with MGUS. The panel also addressed the identification and treatment of MGUS-related skeletal problems, thromboembolic events and neurological complications. The following consensus statement outlines the conclusions and marks the first time that a consensus statement for the screening and treatment of MGUS has been clearly stated.
KW - Fractures
KW - Monoclonal gammopathy of undetermined significance
KW - Osteoporosis
KW - Peripheral neuropathy
UR - http://www.scopus.com/inward/record.url?scp=77953482825&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=77953482825&partnerID=8YFLogxK
U2 - 10.1111/j.1365-2141.2010.08207.x
DO - 10.1111/j.1365-2141.2010.08207.x
M3 - Review article
C2 - 20507313
AN - SCOPUS:77953482825
SN - 0007-1048
VL - 150
SP - 28
EP - 38
JO - British journal of haematology
JF - British journal of haematology
IS - 1
ER -