Monoclonal Gammopathy of Undetermined Significance

Wilson I. Gonsalves, S. Vincent Rajkumar

Research output: Contribution to journalArticlepeer-review

Abstract

Monoclonal gammopathy of undetermined significance (MGUS) is of considerable clinical importance to primary care physicians given its high prevalence in the general population. MGUS has a variable but lifelong risk for progression to hematologic cancer, such as multiple myeloma, Waldenström macroglobulinemia, or light-chain amyloidosis. In addition, MGUS has been associated with several nonmalignant yet symptomatic disorders that require therapy directed toward eliminating the monoclonal gammopathy. Thus, it is important not only to understand the essentials of diagnosing and monitoring patients with MGUS but also to recognize when to refer patients with MGUS to a specialist.

Original languageEnglish (US)
Pages (from-to)177-190
Number of pages14
JournalAnnals of internal medicine
Volume175
Issue number12
DOIs
StatePublished - Dec 1 2022

ASJC Scopus subject areas

  • Internal Medicine

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