Monoclonal gammopathies of undetermined significance and smoldering multiple myeloma

John A. Lust, Diane F Jelinek, Kathleen A. Donovan

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Monoclonal gammopathy of undetermined significance (MGUS) is an asymptomatic, premalignant clonal plasma cell proliferative disorder [1–4]. It was initially referred to as essential hyperglobulinemia by Jan Waldenström, as well as several other terms such as benign, idiopathic, asymptomatic, nonmyelomatous, discrete, cryptogenic, and rudimentary monoclonal gammopathy; dysimmunoglobulinemia; lanthanic monoclonal gammopathy; idiopathic paraproteinemia; and asymptomatic paraimmunoglobulinemia [5, 6]. However, since there is an indefinite risk of progression to multiple myeloma (MM) or related disorder such as macroglobulinemia (WM) or amyloidosis (AL), the term MGUS is now the accepted nomenclature [1, 2, 7, 8]. Smoldering multiple myeloma (SMM) is a clinically defined premalignant stage between MGUS and MM [9, 10]. MGUS and SMM must be differentiated from MM, and from a number of related plasma cell disorders using the criteria listed in see Table 1.2 in Chap. 1 [8, 11].

Original languageEnglish (US)
Title of host publicationMultiple Myeloma: Diagnosis and Treatment
PublisherSpringer New York
Pages65-80
Number of pages16
ISBN (Print)9781461485209, 9781461485193
DOIs
StatePublished - Jan 1 2014

ASJC Scopus subject areas

  • Medicine(all)

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    Lust, J. A., Jelinek, D. F., & Donovan, K. A. (2014). Monoclonal gammopathies of undetermined significance and smoldering multiple myeloma. In Multiple Myeloma: Diagnosis and Treatment (pp. 65-80). Springer New York. https://doi.org/10.1007/978-1-4614-8520-9_7