Monoclonal Epstein-Barr virus-related lymphoproliferative disorder following adult acute lymphoblastic leukaemia

James M. Foran, Sarah E. Slater, Andrew J. Norton, Susanna J. Wilkes, Ian J. Hart, Ama Z.S. Rohatiner

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5 Scopus citations


A 31-year-old patient in remission of acute lymphoblastic leukaemia (ALL), receiving oral maintenance chemotherapy (6-mercaptopurine, methotrexate (MTX), cyclophosphamide), developed a monoclonal, Epstein-Barr virus (EBV)-related lymphoproliferative disorder (LPD). Treatment consisted of excisional biopsy and the discontinuation of maintenance chemotherapy. To our knowledge, this is the first such report in an adult. The histological similarity to previous reports of 'lymphomatoid granulomatosis' following paediatric ALL suggests that they are the same disease. MTX may play a central role in the development of LPD in this setting. Although it is a rare complication of ALL, EBV-related LPD should be considered in patients who develop lymphadenopathy.

Original languageEnglish (US)
Pages (from-to)713-716
Number of pages4
JournalBritish journal of haematology
Issue number3
StatePublished - Sep 24 1999



  • ALL
  • EBV
  • Lymphomatoid granulomatosis
  • Lymphoproliferative disorder
  • Methotrexate

ASJC Scopus subject areas

  • Hematology

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