Monoclonal Epstein-Barr virus-related lymphoproliferative disorder following adult acute lymphoblastic leukaemia

James M Foran, Sarah E. Slater, Andrew J. Norton, Susanna J. Wilkes, Ian J. Hart, Ama Z S Rohatiner

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

A 31-year-old patient in remission of acute lymphoblastic leukaemia (ALL), receiving oral maintenance chemotherapy (6-mercaptopurine, methotrexate (MTX), cyclophosphamide), developed a monoclonal, Epstein-Barr virus (EBV)-related lymphoproliferative disorder (LPD). Treatment consisted of excisional biopsy and the discontinuation of maintenance chemotherapy. To our knowledge, this is the first such report in an adult. The histological similarity to previous reports of 'lymphomatoid granulomatosis' following paediatric ALL suggests that they are the same disease. MTX may play a central role in the development of LPD in this setting. Although it is a rare complication of ALL, EBV-related LPD should be considered in patients who develop lymphadenopathy.

Original languageEnglish (US)
Pages (from-to)713-716
Number of pages4
JournalBritish Journal of Haematology
Volume106
Issue number3
DOIs
StatePublished - 1999
Externally publishedYes

Fingerprint

Lymphoproliferative Disorders
Human Herpesvirus 4
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Maintenance Chemotherapy
Methotrexate
Lymphomatoid Granulomatosis
6-Mercaptopurine
Cyclophosphamide
Pediatrics
Biopsy
Therapeutics

Keywords

  • ALL
  • EBV
  • Lymphomatoid granulomatosis
  • Lymphoproliferative disorder
  • Methotrexate

ASJC Scopus subject areas

  • Hematology

Cite this

Monoclonal Epstein-Barr virus-related lymphoproliferative disorder following adult acute lymphoblastic leukaemia. / Foran, James M; Slater, Sarah E.; Norton, Andrew J.; Wilkes, Susanna J.; Hart, Ian J.; Rohatiner, Ama Z S.

In: British Journal of Haematology, Vol. 106, No. 3, 1999, p. 713-716.

Research output: Contribution to journalArticle

Foran, James M ; Slater, Sarah E. ; Norton, Andrew J. ; Wilkes, Susanna J. ; Hart, Ian J. ; Rohatiner, Ama Z S. / Monoclonal Epstein-Barr virus-related lymphoproliferative disorder following adult acute lymphoblastic leukaemia. In: British Journal of Haematology. 1999 ; Vol. 106, No. 3. pp. 713-716.
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