Monoclonal B cell lymphocytosis: Clinical and population perspectives

Neil E. Caporaso, Gerald E. Marti, Ola Landgren, Elizabeth Azzato, J. Brice Weinberg, Lynn Goldin, Tait Shanafelt

Research output: Contribution to journalReview article

6 Scopus citations

Abstract

Monoclonal B Cell Lymphocytosis (MBL) refers to clones of CLL-like cells that exhibit CLL characteristics that fall short of the numbers required for CLL diagnosis. Data from large CLL kindreds document increased prevalence of MBL suggesting a genetic contribution to its etiology. The molecular features that favor progression of MBL to CLL are poorly understood but an elevated B-cell count is a risk factor for progression. An important consideration when evaluating volunteers from CLL families who are willing to donate bone marrow is that MBL be ruled out since the MBL donor clone could result in a second CLL in the recipient. Further studies of MBL are needed to identify the molecular features and how they evolve during progression.

Original languageEnglish (US)
Pages (from-to)S115-S119
JournalCytometry Part B - Clinical Cytometry
Volume78
Issue numberSUPPL. 1
DOIs
StatePublished - Sep 20 2010

Keywords

  • Chronic lymphocytic leukemia
  • Lymphocytosis
  • Monoclonal B cell lymphocytosis
  • Population

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Histology
  • Cell Biology

Fingerprint Dive into the research topics of 'Monoclonal B cell lymphocytosis: Clinical and population perspectives'. Together they form a unique fingerprint.

  • Cite this

    Caporaso, N. E., Marti, G. E., Landgren, O., Azzato, E., Weinberg, J. B., Goldin, L., & Shanafelt, T. (2010). Monoclonal B cell lymphocytosis: Clinical and population perspectives. Cytometry Part B - Clinical Cytometry, 78(SUPPL. 1), S115-S119. https://doi.org/10.1002/cyto.b.20555