Monoclonal B cell lymphocytosis: Clinical and population perspectives

Neil E. Caporaso, Gerald E. Marti, Ola Landgren, Elizabeth Azzato, J. Brice Weinberg, Lynn Goldin, Tait Shanafelt

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Monoclonal B Cell Lymphocytosis (MBL) refers to clones of CLL-like cells that exhibit CLL characteristics that fall short of the numbers required for CLL diagnosis. Data from large CLL kindreds document increased prevalence of MBL suggesting a genetic contribution to its etiology. The molecular features that favor progression of MBL to CLL are poorly understood but an elevated B-cell count is a risk factor for progression. An important consideration when evaluating volunteers from CLL families who are willing to donate bone marrow is that MBL be ruled out since the MBL donor clone could result in a second CLL in the recipient. Further studies of MBL are needed to identify the molecular features and how they evolve during progression.

Original languageEnglish (US)
JournalCytometry Part B - Clinical Cytometry
Volume78
Issue numberSUPPL. 1
DOIs
StatePublished - 2010

Fingerprint

Lymphocytosis
B-Lymphocytes
Population
Clone Cells
Volunteers
Cell Count
Bone Marrow
Tissue Donors

Keywords

  • Chronic lymphocytic leukemia
  • Lymphocytosis
  • Monoclonal B cell lymphocytosis
  • Population

ASJC Scopus subject areas

  • Cell Biology
  • Histology
  • Pathology and Forensic Medicine

Cite this

Caporaso, N. E., Marti, G. E., Landgren, O., Azzato, E., Weinberg, J. B., Goldin, L., & Shanafelt, T. (2010). Monoclonal B cell lymphocytosis: Clinical and population perspectives. Cytometry Part B - Clinical Cytometry, 78(SUPPL. 1). https://doi.org/10.1002/cyto.b.20555

Monoclonal B cell lymphocytosis : Clinical and population perspectives. / Caporaso, Neil E.; Marti, Gerald E.; Landgren, Ola; Azzato, Elizabeth; Weinberg, J. Brice; Goldin, Lynn; Shanafelt, Tait.

In: Cytometry Part B - Clinical Cytometry, Vol. 78, No. SUPPL. 1, 2010.

Research output: Contribution to journalArticle

Caporaso, NE, Marti, GE, Landgren, O, Azzato, E, Weinberg, JB, Goldin, L & Shanafelt, T 2010, 'Monoclonal B cell lymphocytosis: Clinical and population perspectives', Cytometry Part B - Clinical Cytometry, vol. 78, no. SUPPL. 1. https://doi.org/10.1002/cyto.b.20555
Caporaso NE, Marti GE, Landgren O, Azzato E, Weinberg JB, Goldin L et al. Monoclonal B cell lymphocytosis: Clinical and population perspectives. Cytometry Part B - Clinical Cytometry. 2010;78(SUPPL. 1). https://doi.org/10.1002/cyto.b.20555
Caporaso, Neil E. ; Marti, Gerald E. ; Landgren, Ola ; Azzato, Elizabeth ; Weinberg, J. Brice ; Goldin, Lynn ; Shanafelt, Tait. / Monoclonal B cell lymphocytosis : Clinical and population perspectives. In: Cytometry Part B - Clinical Cytometry. 2010 ; Vol. 78, No. SUPPL. 1.
@article{693f5f0c36fe482985ed1f6e3a07c6ee,
title = "Monoclonal B cell lymphocytosis: Clinical and population perspectives",
abstract = "Monoclonal B Cell Lymphocytosis (MBL) refers to clones of CLL-like cells that exhibit CLL characteristics that fall short of the numbers required for CLL diagnosis. Data from large CLL kindreds document increased prevalence of MBL suggesting a genetic contribution to its etiology. The molecular features that favor progression of MBL to CLL are poorly understood but an elevated B-cell count is a risk factor for progression. An important consideration when evaluating volunteers from CLL families who are willing to donate bone marrow is that MBL be ruled out since the MBL donor clone could result in a second CLL in the recipient. Further studies of MBL are needed to identify the molecular features and how they evolve during progression.",
keywords = "Chronic lymphocytic leukemia, Lymphocytosis, Monoclonal B cell lymphocytosis, Population",
author = "Caporaso, {Neil E.} and Marti, {Gerald E.} and Ola Landgren and Elizabeth Azzato and Weinberg, {J. Brice} and Lynn Goldin and Tait Shanafelt",
year = "2010",
doi = "10.1002/cyto.b.20555",
language = "English (US)",
volume = "78",
journal = "Cytometry",
issn = "1552-4949",
publisher = "John Wiley and Sons Inc.",
number = "SUPPL. 1",

}

TY - JOUR

T1 - Monoclonal B cell lymphocytosis

T2 - Clinical and population perspectives

AU - Caporaso, Neil E.

AU - Marti, Gerald E.

AU - Landgren, Ola

AU - Azzato, Elizabeth

AU - Weinberg, J. Brice

AU - Goldin, Lynn

AU - Shanafelt, Tait

PY - 2010

Y1 - 2010

N2 - Monoclonal B Cell Lymphocytosis (MBL) refers to clones of CLL-like cells that exhibit CLL characteristics that fall short of the numbers required for CLL diagnosis. Data from large CLL kindreds document increased prevalence of MBL suggesting a genetic contribution to its etiology. The molecular features that favor progression of MBL to CLL are poorly understood but an elevated B-cell count is a risk factor for progression. An important consideration when evaluating volunteers from CLL families who are willing to donate bone marrow is that MBL be ruled out since the MBL donor clone could result in a second CLL in the recipient. Further studies of MBL are needed to identify the molecular features and how they evolve during progression.

AB - Monoclonal B Cell Lymphocytosis (MBL) refers to clones of CLL-like cells that exhibit CLL characteristics that fall short of the numbers required for CLL diagnosis. Data from large CLL kindreds document increased prevalence of MBL suggesting a genetic contribution to its etiology. The molecular features that favor progression of MBL to CLL are poorly understood but an elevated B-cell count is a risk factor for progression. An important consideration when evaluating volunteers from CLL families who are willing to donate bone marrow is that MBL be ruled out since the MBL donor clone could result in a second CLL in the recipient. Further studies of MBL are needed to identify the molecular features and how they evolve during progression.

KW - Chronic lymphocytic leukemia

KW - Lymphocytosis

KW - Monoclonal B cell lymphocytosis

KW - Population

UR - http://www.scopus.com/inward/record.url?scp=77956600320&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=77956600320&partnerID=8YFLogxK

U2 - 10.1002/cyto.b.20555

DO - 10.1002/cyto.b.20555

M3 - Article

C2 - 20839332

AN - SCOPUS:77956600320

VL - 78

JO - Cytometry

JF - Cytometry

SN - 1552-4949

IS - SUPPL. 1

ER -