Monoclonal antibody (mAb)-based cancer therapy: Is it time to reevaluate dosing strategies?

Margaret A. Lindorfer, Adrian Wiestner, Clive S. Zent, Ronald P. Taylor

Research output: Contribution to journalArticle

19 Scopus citations

Abstract

Compelling evidence indicates type I CD20 immunotherapeutic mAbs promote targeted tumor cell elimination exclusively via immune efector functions, which can be exhausted/saturated. mAb dosing paradigms should therefore take into account the capacity of these cytotoxic mechanisms, leading to the conclusion that lower doses, given frequently, may be far more efective.

Original languageEnglish (US)
Pages (from-to)959-961
Number of pages3
JournalOncoImmunology
Volume1
Issue number6
DOIs
StatePublished - 2012

Keywords

  • CD20 mAbs
  • Immunomonitoring
  • Therapeutic antibodies
  • Therapeutic trials
  • Trogocytosis

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Oncology

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