Monitoring activity of fibrinolytic agents. A therapeutic challenge

Kenneth E. Shafer; Samuel A. Santoro; Burton E. Sobel; Allan S. Jaffe

doi:10.1016/0002-9343(84)91003-9

Monitoring activity of fibrinolytic agents. A therapeutic challenge

Kenneth E. Shafer, Samuel A. Santoro, Burton E. Sobel, Allan S. Jaffe

Cardiovascular Medicine

Research output: Contribution to journal › Review article

29 Scopus citations

Abstract

The recognition that thrombolytic therapy may be beneficial for coronary thrombolysis has led to an increased use of plasminogen activators in critically ill patients, sometimes with inadequate monitoring. This review delineates the components of the fibrinolytic system, describes mechanisms of fibrinolysis, and presents practical guidelines for monitoring the use of activators of the system.

Original language	English (US)
Pages (from-to)	879-886
Number of pages	8
Journal	The American Journal of Medicine
Volume	76
Issue number	5
DOIs	https://doi.org/10.1016/0002-9343(84)91003-9
State	Published - May 1984

ASJC Scopus subject areas

Medicine(all)

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10.1016/0002-9343(84)91003-9

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Shafer, K. E., Santoro, S. A., Sobel, B. E., & Jaffe, A. S. (1984). Monitoring activity of fibrinolytic agents. A therapeutic challenge. The American Journal of Medicine, 76(5), 879-886. https://doi.org/10.1016/0002-9343(84)91003-9

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title = "Monitoring activity of fibrinolytic agents. A therapeutic challenge",

abstract = "The recognition that thrombolytic therapy may be beneficial for coronary thrombolysis has led to an increased use of plasminogen activators in critically ill patients, sometimes with inadequate monitoring. This review delineates the components of the fibrinolytic system, describes mechanisms of fibrinolysis, and presents practical guidelines for monitoring the use of activators of the system.",

author = "Shafer, {Kenneth E.} and Santoro, {Samuel A.} and Sobel, {Burton E.} and Jaffe, {Allan S.}",

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AB - The recognition that thrombolytic therapy may be beneficial for coronary thrombolysis has led to an increased use of plasminogen activators in critically ill patients, sometimes with inadequate monitoring. This review delineates the components of the fibrinolytic system, describes mechanisms of fibrinolysis, and presents practical guidelines for monitoring the use of activators of the system.

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