Molecular views of Arf-like small GTPases in cilia and ciliopathies

Qing Zhang, Jinghua Hu, Kun Ling

Research output: Contribution to journalReview article

25 Scopus citations

Abstract

The primary cilia are microtubule-based organelles that protrude from most of the eukaryotic cells. Recognized as the cell's antenna, primary cilium functions as a signaling hub for many physiologically and developmentally important signaling cascades. Ciliary dysfunction causes a wide spectrum of syndromic human genetic diseases collectively termed "ciliopathies". Mounting evidences have shown that various small GTPases have been implicated in the context of cilia as well as human ciliopathies. However, how these small GTPases affect cilia formation and function remains poorly understood. Here we review and discuss the ciliary role of three Arf-like small GTPases (Arls), Arl3, Arl6, and Arl13b.

Original languageEnglish (US)
Pages (from-to)2316-2322
Number of pages7
JournalExperimental Cell Research
Volume319
Issue number15
DOIs
StatePublished - Sep 10 2013

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Keywords

  • Arl
  • Cilia
  • Ciliopathy
  • Small GTPase

ASJC Scopus subject areas

  • Cell Biology

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