Molecular targets of glioma invasion

M. Nakada, S. Nakada, T. Demuth, N. L. Tran, D. B. Hoelzinger, M. E. Berens

Research output: Contribution to journalReview article

288 Scopus citations

Abstract

Glioblastoma multiforme is the most common and lethal primary malignant brain tumor. Although considerable progress has been made in technical proficiencies of surgical and radiation treatment for brain tumor patients, the impact of these advances on clinical outcome has been disappointing, with median survival time not exceeding 15 months. Over the last 30 years, no significant increase in survival of patients suffering from this disease has been achieved. A fundamental source of the management challenge presented in glioma patients is the insidious propensity of tumor invasion into distant brain tissue. Invasive tumor cells escape surgical removal and geographically dodge lethal radiation exposure and chemotherapy. Recent improved understanding of biochemical and molecular determinants of glioma cell invasion provide valuable insight into the underlying biological features of the disease, as well as illuminating possible new therapeutic targets. These findings are moving forward to translational research and clinical trials as novel antiglioma therapies.

Original languageEnglish (US)
Pages (from-to)458-478
Number of pages21
JournalCellular and Molecular Life Sciences
Volume64
Issue number4
DOIs
StatePublished - Feb 1 2007

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Keywords

  • Glioma
  • Invasion

ASJC Scopus subject areas

  • Molecular Medicine
  • Molecular Biology
  • Pharmacology
  • Cellular and Molecular Neuroscience
  • Cell Biology

Cite this

Nakada, M., Nakada, S., Demuth, T., Tran, N. L., Hoelzinger, D. B., & Berens, M. E. (2007). Molecular targets of glioma invasion. Cellular and Molecular Life Sciences, 64(4), 458-478. https://doi.org/10.1007/s00018-007-6342-5