Molecular regulation of androgen action in prostate cancer

Scott M. Dehm, Donald J. Tindall

Research output: Contribution to journalReview article

213 Scopus citations

Abstract

Androgens are critical regulators of prostate differentiation and function, as well as prostate cancer growth and survival. Therefore, androgen ablation is the preferred systemic treatment for disseminated prostate cancer. Androgen action is exerted in target tissues via binding the androgen receptor (AR), a nuclear receptor transcription factor. Historically, the gene expression program mediated by the AR has been poorly understood. However, recent gene expression profiling and more traditional single-gene characterization studies have revealed many androgen-regulated genes that are important mediators of androgen action in both normal and malignant prostate tissue. This review will focus on the androgen-regulated gene expression program, and examine how recently identified androgen-regulated genes are likely to contribute to the development and progression of prostate cancer. We will also summarize several recent studies that have attempted to unravel how these genes are deregulated in androgen depletion independent prostate cancer.

Original languageEnglish (US)
Pages (from-to)333-344
Number of pages12
JournalJournal of cellular biochemistry
Volume99
Issue number2
DOIs
StatePublished - Oct 1 2006

Keywords

  • Androgen receptor
  • Gene expression
  • Prostate cancer
  • Transcription

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

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