Molecular pathways of pancreatic carcinogenesis

Research output: Contribution to journalReview article

6 Scopus citations

Abstract

Pancreatic cancer has one of the poorest prognoses among human neoplasms, with an overall five-year survival rate of 3%. Thus, there are significant efforts to understand the molecular mechanisms underlying the development pancreatic cancer that might lead to effective diagnostic and treatment strategies that improve the prognosis of the disease. In this review, we discuss signaling pathways that control cell growth, differentiation and migration that are dysregulated in this cancer. Particular emphasis is given to the potential there is to manipulate these pathways for therapeutic purposes.

Original languageEnglish (US)
Pages (from-to)247-252
Number of pages6
JournalDrug Discovery Today: Disease Mechanisms
Volume1
Issue number2
DOIs
StatePublished - Nov 2004

ASJC Scopus subject areas

  • Molecular Medicine
  • Drug Discovery

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