Molecular pathology of adverse local tissue reaction caused by metal-on-metal implants defined by RNA-seq

Christopher G. Salib; Eric A. Lewallen; Christopher R. Paradise; Meagan E. Tibbo; Joseph X. Robin; William H. Trousdale; Logan M. Morrey; Jason Xiao; Travis W. Turner; Afton K. Limberg; Anthony G. Jay; Roman Thaler; Amel Dudakovic; Joaquin Sanchez-Sotelo; Mark E. Morrey; Daniel J. Berry; David G. Lewallen; Andre J. van Wijnen; Matthew P. Abdel

doi:10.1016/j.ygeno.2018.09.013

Molecular pathology of adverse local tissue reaction caused by metal-on-metal implants defined by RNA-seq

Christopher G. Salib, Eric A. Lewallen, Christopher R. Paradise, Meagan E. Tibbo, Joseph X. Robin, William H. Trousdale, Logan M. Morrey, Jason Xiao, Travis W. Turner, Afton K. Limberg, Anthony G. Jay, Roman Thaler, Amel Dudakovic, Joaquin Sanchez-Sotelo, Mark E. Morrey, Daniel J. Berry, David G. Lewallen, Andre J. van Wijnen, Matthew P. Abdel

Orthopedic Surgery

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

Total hip arthroplasty (THA) alleviates hip pain and improves joint function. Current implant design permits long-term survivorship of THAs, but certain metal-on-metal (MoM) articulations can portend catastrophic failure due to adverse local tissue reactions (ALTR). Here, we identified biological and molecular differences between periacetabular synovial tissues of patients with MoM THA failure undergoing revision THA compared to patients undergoing primary THA for routine osteoarthritis (OA). Analysis of tissue biopsies by RNA-sequencing (RNA-seq) revealed that MoM patient samples exhibit significantly increased expression of immune response genes but decreased expression of genes related to extracellular matrix (ECM) remodeling. Thus, interplay between local tissue inflammation and ECM degradation may account for the pathology and compromised clinical outcomes in select patients with MoM implants. We conclude that adverse responses of host tissues to implant materials result in transcriptomic modifications in patients with MoM implants that permit consideration of strategies that could mitigate ECM damage.

Original language	English (US)
Pages (from-to)	1404-1411
Number of pages	8
Journal	Genomics
Volume	111
Issue number	6
DOIs	https://doi.org/10.1016/j.ygeno.2018.09.013
State	Published - Dec 2019

Keywords

Adverse local tissue reaction
Cell biology
Metal-on-metal
Metallosis
Molecular genetics
Total hip arthroplasty

ASJC Scopus subject areas

Genetics

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10.1016/j.ygeno.2018.09.013

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Salib, C. G., Lewallen, E. A., Paradise, C. R., Tibbo, M. E., Robin, J. X., Trousdale, W. H., Morrey, L. M., Xiao, J., Turner, T. W., Limberg, A. K., Jay, A. G., Thaler, R., Dudakovic, A., Sanchez-Sotelo, J., Morrey, M. E., Berry, D. J., Lewallen, D. G., van Wijnen, A. J., & Abdel, M. P. (2019). Molecular pathology of adverse local tissue reaction caused by metal-on-metal implants defined by RNA-seq. Genomics, 111(6), 1404-1411. https://doi.org/10.1016/j.ygeno.2018.09.013

Salib, CG, Lewallen, EA, Paradise, CR, Tibbo, ME, Robin, JX, Trousdale, WH, Morrey, LM, Xiao, J, Turner, TW, Limberg, AK, Jay, AG, Thaler, R, Dudakovic, A, Sanchez-Sotelo, J, Morrey, ME, Berry, DJ, Lewallen, DG, van Wijnen, AJ & Abdel, MP 2019, 'Molecular pathology of adverse local tissue reaction caused by metal-on-metal implants defined by RNA-seq', Genomics, vol. 111, no. 6, pp. 1404-1411. https://doi.org/10.1016/j.ygeno.2018.09.013

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title = "Molecular pathology of adverse local tissue reaction caused by metal-on-metal implants defined by RNA-seq",

abstract = "Total hip arthroplasty (THA) alleviates hip pain and improves joint function. Current implant design permits long-term survivorship of THAs, but certain metal-on-metal (MoM) articulations can portend catastrophic failure due to adverse local tissue reactions (ALTR). Here, we identified biological and molecular differences between periacetabular synovial tissues of patients with MoM THA failure undergoing revision THA compared to patients undergoing primary THA for routine osteoarthritis (OA). Analysis of tissue biopsies by RNA-sequencing (RNA-seq) revealed that MoM patient samples exhibit significantly increased expression of immune response genes but decreased expression of genes related to extracellular matrix (ECM) remodeling. Thus, interplay between local tissue inflammation and ECM degradation may account for the pathology and compromised clinical outcomes in select patients with MoM implants. We conclude that adverse responses of host tissues to implant materials result in transcriptomic modifications in patients with MoM implants that permit consideration of strategies that could mitigate ECM damage.",

keywords = "Adverse local tissue reaction, Cell biology, Metal-on-metal, Metallosis, Molecular genetics, Total hip arthroplasty",

author = "Salib, {Christopher G.} and Lewallen, {Eric A.} and Paradise, {Christopher R.} and Tibbo, {Meagan E.} and Robin, {Joseph X.} and Trousdale, {William H.} and Morrey, {Logan M.} and Jason Xiao and Turner, {Travis W.} and Limberg, {Afton K.} and Jay, {Anthony G.} and Roman Thaler and Amel Dudakovic and Joaquin Sanchez-Sotelo and Morrey, {Mark E.} and Berry, {Daniel J.} and Lewallen, {David G.} and {van Wijnen}, {Andre J.} and Abdel, {Matthew P.}",

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year = "2019",

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AU - Paradise, Christopher R.

AU - Tibbo, Meagan E.

AU - Robin, Joseph X.

AU - Trousdale, William H.

AU - Morrey, Logan M.

AU - Xiao, Jason

AU - Turner, Travis W.

AU - Limberg, Afton K.

AU - Jay, Anthony G.

AU - Thaler, Roman

AU - Dudakovic, Amel

AU - Sanchez-Sotelo, Joaquin

AU - Morrey, Mark E.

AU - Berry, Daniel J.

AU - Lewallen, David G.

AU - van Wijnen, Andre J.

AU - Abdel, Matthew P.

PY - 2019/12

Y1 - 2019/12

N2 - Total hip arthroplasty (THA) alleviates hip pain and improves joint function. Current implant design permits long-term survivorship of THAs, but certain metal-on-metal (MoM) articulations can portend catastrophic failure due to adverse local tissue reactions (ALTR). Here, we identified biological and molecular differences between periacetabular synovial tissues of patients with MoM THA failure undergoing revision THA compared to patients undergoing primary THA for routine osteoarthritis (OA). Analysis of tissue biopsies by RNA-sequencing (RNA-seq) revealed that MoM patient samples exhibit significantly increased expression of immune response genes but decreased expression of genes related to extracellular matrix (ECM) remodeling. Thus, interplay between local tissue inflammation and ECM degradation may account for the pathology and compromised clinical outcomes in select patients with MoM implants. We conclude that adverse responses of host tissues to implant materials result in transcriptomic modifications in patients with MoM implants that permit consideration of strategies that could mitigate ECM damage.

AB - Total hip arthroplasty (THA) alleviates hip pain and improves joint function. Current implant design permits long-term survivorship of THAs, but certain metal-on-metal (MoM) articulations can portend catastrophic failure due to adverse local tissue reactions (ALTR). Here, we identified biological and molecular differences between periacetabular synovial tissues of patients with MoM THA failure undergoing revision THA compared to patients undergoing primary THA for routine osteoarthritis (OA). Analysis of tissue biopsies by RNA-sequencing (RNA-seq) revealed that MoM patient samples exhibit significantly increased expression of immune response genes but decreased expression of genes related to extracellular matrix (ECM) remodeling. Thus, interplay between local tissue inflammation and ECM degradation may account for the pathology and compromised clinical outcomes in select patients with MoM implants. We conclude that adverse responses of host tissues to implant materials result in transcriptomic modifications in patients with MoM implants that permit consideration of strategies that could mitigate ECM damage.

KW - Adverse local tissue reaction

KW - Cell biology

KW - Metal-on-metal

KW - Metallosis

KW - Molecular genetics

KW - Total hip arthroplasty

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Molecular pathology of adverse local tissue reaction caused by metal-on-metal implants defined by RNA-seq

Abstract

Keywords

ASJC Scopus subject areas

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