@article{95011e376f974620b94f5f407e6b33ad,
title = "Molecular pathology of adverse local tissue reaction caused by metal-on-metal implants defined by RNA-seq",
abstract = "Total hip arthroplasty (THA) alleviates hip pain and improves joint function. Current implant design permits long-term survivorship of THAs, but certain metal-on-metal (MoM) articulations can portend catastrophic failure due to adverse local tissue reactions (ALTR). Here, we identified biological and molecular differences between periacetabular synovial tissues of patients with MoM THA failure undergoing revision THA compared to patients undergoing primary THA for routine osteoarthritis (OA). Analysis of tissue biopsies by RNA-sequencing (RNA-seq) revealed that MoM patient samples exhibit significantly increased expression of immune response genes but decreased expression of genes related to extracellular matrix (ECM) remodeling. Thus, interplay between local tissue inflammation and ECM degradation may account for the pathology and compromised clinical outcomes in select patients with MoM implants. We conclude that adverse responses of host tissues to implant materials result in transcriptomic modifications in patients with MoM implants that permit consideration of strategies that could mitigate ECM damage.",
keywords = "Adverse local tissue reaction, Cell biology, Metal-on-metal, Metallosis, Molecular genetics, Total hip arthroplasty",
author = "Salib, {Christopher G.} and Lewallen, {Eric A.} and Paradise, {Christopher R.} and Tibbo, {Meagan E.} and Robin, {Joseph X.} and Trousdale, {William H.} and Morrey, {Logan M.} and Jason Xiao and Turner, {Travis W.} and Limberg, {Afton K.} and Jay, {Anthony G.} and Roman Thaler and Amel Dudakovic and Joaquin Sanchez-Sotelo and Morrey, {Mark E.} and Berry, {Daniel J.} and Lewallen, {David G.} and {van Wijnen}, {Andre J.} and Abdel, {Matthew P.}",
note = "Funding Information: We thank members of the Abdel and van Wijnen laboratories, and in particular Anthony Viste, Nic Reina, Carter Jones, Jie ({\textquoteleft}Jay{\textquoteright}) Yao and Scott Riester for stimulating discussions and/or assistance with reagents and procedures. Research reported in this publication was supported by the National Institutes of Arthritis and Musculoskeletal and Skin Disease of the National Institute of Health under Award Numbers R01 AR072597 for MPA, R01 AR049069 for AJVW, and F32 AR068154 for EAL. The Mayo Clinic Center for Regenerative Medicine also provided a Post-doctoral Career Development Award to Roman Thaler. We also appreciate the generous philanthropic support of Anna-Maria and Stephen Kellen Foundation and William H. and Karen J. Eby, and the charitable foundations in their names. Matthew P. Abdel, M.D. is a paid consultant for Stryker. Daniel J. Berry, M.D. receives royalties from DePuy, and David G. Lewallen, M.D. receives royalties from Zimmer-Biomet. No other authors have conflicts of interest to disclosure. Funding Information: We thank members of the Abdel and van Wijnen laboratories, and in particular Anthony Viste, Nic Reina, Carter Jones, Jie (?Jay?) Yao and Scott Riester for stimulating discussions and/or assistance with reagents and procedures. Research reported in this publication was supported by the National Institutes of Arthritis and Musculoskeletal and Skin Disease of the National Institute of Health under Award Numbers R01 AR072597 for MPA, R01 AR049069 for AJVW, and F32 AR068154 for EAL. The Mayo Clinic Center for Regenerative Medicine also provided a Post-doctoral Career Development Award to Roman Thaler. We also appreciate the generous philanthropic support of Anna-Maria and Stephen Kellen Foundation and William H. and Karen J. Eby, and the charitable foundations in their names. Matthew P. Abdel, M.D. is a paid consultant for Stryker. Daniel J. Berry, M.D. receives royalties from DePuy, and David G. Lewallen, M.D. receives royalties from Zimmer-Biomet. No other authors have conflicts of interest to disclosure. Publisher Copyright: {\textcopyright} 2018 Elsevier Inc.",
year = "2019",
month = dec,
doi = "10.1016/j.ygeno.2018.09.013",
language = "English (US)",
volume = "111",
pages = "1404--1411",
journal = "Genomics",
issn = "0888-7543",
publisher = "Academic Press Inc.",
number = "6",
}