Molecular pathogenesis of Waldenström's macroglobulinemia

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Waldenström's macroglobulinemia is an indolent, lymphoproliferative disease, characterized by a heterogeneous lymphoplasmacytic bone marrow infiltrate and high immunoglobulin M production. While technological advances over the past several decades have dramatically improved the possibilities of studying the molecular basis of Waldenström's macroglobulinemia, the pathogenesis of the disease remains fragmented. Undoubtedly, research has been successful in uncovering underlying aberrations and deregulated mechanisms in this disease, providing useful information for identifying biomarkers for disease diagnosis, risk stratification and therapeutic intervention, but there is still a long way to go before the pathogenesis of Waldenström's macroglobulinemia is fully revealed. In addition, the low number of in vitro or in vivomodels significantly challenges extensive analysis. In this manuscript, we review the molecular basis of this disease.

Original languageEnglish (US)
Pages (from-to)1281-1290
Number of pages10
JournalHaematologica
Volume97
Issue number9
DOIs
StatePublished - Sep 1 2012

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Waldenstrom Macroglobulinemia
Immunoglobulin M
Biomarkers
Bone Marrow
Research

Keywords

  • aCGH
  • IL-6
  • Jak/STAT
  • PI3K/Akt
  • WM, NF-kB signaling pathway

ASJC Scopus subject areas

  • Hematology

Cite this

Molecular pathogenesis of Waldenström's macroglobulinemia. / Braggio, Esteban D; Philipsborn, Casey; Novak, Anne J; Hodge, Lucy; Ansell, Stephen Maxted; Fonseca, Rafael.

In: Haematologica, Vol. 97, No. 9, 01.09.2012, p. 1281-1290.

Research output: Contribution to journalArticle

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AU - Fonseca, Rafael

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