TY - JOUR
T1 - Molecular pathogenesis of hepatocellular carcinoma and impact of therapeutic advances [version 1; referees
T2 - 4 approved]
AU - Dhanasekaran, Renumathy
AU - Bandoh, Salome
AU - Roberts, Lewis R.
N1 - Publisher Copyright:
© 2016 Dhanasekaran R et al.
PY - 2016
Y1 - 2016
N2 - Hepatocellular carcinoma (HCC) is a leading cause of cancer mortality and has an increasing incidence worldwide. HCC can be induced by multiple etiologies, is influenced by many risk factors, and has a complex pathogenesis. Furthermore, HCCs exhibit substantial heterogeneity, which compounds the difficulties in developing effective therapies against this highly lethal cancer. With advances in cancer biology and molecular and genetic profiling, a number of different mechanisms involved in the development and progression of HCC have been identified. Despite the advances in this area, the molecular pathogenesis of hepatocellular carcinoma is still not completely understood. This review aims to elaborate our current understanding of the most relevant genetic alterations and molecular pathways involved in the development and progression of HCC, and anticipate the potential impact of future advances on therapeutic drug development.
AB - Hepatocellular carcinoma (HCC) is a leading cause of cancer mortality and has an increasing incidence worldwide. HCC can be induced by multiple etiologies, is influenced by many risk factors, and has a complex pathogenesis. Furthermore, HCCs exhibit substantial heterogeneity, which compounds the difficulties in developing effective therapies against this highly lethal cancer. With advances in cancer biology and molecular and genetic profiling, a number of different mechanisms involved in the development and progression of HCC have been identified. Despite the advances in this area, the molecular pathogenesis of hepatocellular carcinoma is still not completely understood. This review aims to elaborate our current understanding of the most relevant genetic alterations and molecular pathways involved in the development and progression of HCC, and anticipate the potential impact of future advances on therapeutic drug development.
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U2 - 10.12688/F1000RESEARCH.6946.1
DO - 10.12688/F1000RESEARCH.6946.1
M3 - Review article
AN - SCOPUS:85010850447
SN - 2046-1402
VL - 5
JO - F1000Research
JF - F1000Research
M1 - 879
ER -