Molecular Pathogenesis of Barrett Esophagus: Current Evidence

Kausilia K. Krishnadath, Kenneth Ke Ning Wang

Research output: Contribution to journalArticlepeer-review

6 Scopus citations

Abstract

This article focuses on recent findings on the molecular mechanisms involved in esophageal columnar metaplasia. Signaling pathways and their downstream targets activate specific transcription factors leading to the expression of columnar and the more specific intestinal-type of genes, which gives rise to Barrett metaplasia. Several animal models have been generated to validate and study these distinct molecular pathways but also to identify the Barrett progenitor cell. Currently, the many aspects involved in the development of esophageal metaplasia that have been elucidated can serve to develop novel molecular therapies to improve treatment or prevent metaplasia. Nevertheless, several key events are still poorly understood and require further investigation.

Original languageEnglish (US)
Pages (from-to)233-247
Number of pages15
JournalGastroenterology Clinics of North America
Volume44
Issue number2
DOIs
StatePublished - Jun 1 2015

Keywords

  • BMP4
  • CDX2
  • Lineage tracing
  • Notch
  • P63
  • PSMAD
  • SSH
  • WNT

ASJC Scopus subject areas

  • Gastroenterology

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