Molecular mechanisms of thyroid hormone action

A. R. Shepard; N. L. Eberhardt

doi:10.1016/s0272-2712(18)30424-4

Molecular mechanisms of thyroid hormone action

A. R. Shepard, N. L. Eberhardt

Endocrinology, Diabetes, Metabolism, and Nutrition

Research output: Contribution to journal › Review article › peer-review

16 Scopus citations

Abstract

This review summarizes our current understanding of the mechanisms of thyroid hormone action. Topics included are the structures of thyroid hormone response elements (TREs), thyroid hormone receptor (TR)-TRE interactions, and TR association with other proteins to illustrate their importance in modulating both positive and negative transcriptional activation of specific genes. Certain studies focusing on other members of the steroid/thyroid hormone receptor superfamily are covered to provide a current view of how this class of receptors stabilizes transcription initiation complexes.

Original language	English (US)
Pages (from-to)	531-541
Number of pages	11
Journal	Clinics in Laboratory Medicine
Volume	13
Issue number	3
DOIs	https://doi.org/10.1016/s0272-2712(18)30424-4
State	Published - 1993

ASJC Scopus subject areas

Clinical Biochemistry
Biochemistry, medical

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10.1016/s0272-2712(18)30424-4

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abstract = "This review summarizes our current understanding of the mechanisms of thyroid hormone action. Topics included are the structures of thyroid hormone response elements (TREs), thyroid hormone receptor (TR)-TRE interactions, and TR association with other proteins to illustrate their importance in modulating both positive and negative transcriptional activation of specific genes. Certain studies focusing on other members of the steroid/thyroid hormone receptor superfamily are covered to provide a current view of how this class of receptors stabilizes transcription initiation complexes.",

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AB - This review summarizes our current understanding of the mechanisms of thyroid hormone action. Topics included are the structures of thyroid hormone response elements (TREs), thyroid hormone receptor (TR)-TRE interactions, and TR association with other proteins to illustrate their importance in modulating both positive and negative transcriptional activation of specific genes. Certain studies focusing on other members of the steroid/thyroid hormone receptor superfamily are covered to provide a current view of how this class of receptors stabilizes transcription initiation complexes.

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Molecular mechanisms of thyroid hormone action

Abstract

ASJC Scopus subject areas

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