Molecular mechanisms of thyroid hormone action

A. R. Shepard, N. L. Eberhardt

Research output: Contribution to journalReview article

16 Scopus citations

Abstract

This review summarizes our current understanding of the mechanisms of thyroid hormone action. Topics included are the structures of thyroid hormone response elements (TREs), thyroid hormone receptor (TR)-TRE interactions, and TR association with other proteins to illustrate their importance in modulating both positive and negative transcriptional activation of specific genes. Certain studies focusing on other members of the steroid/thyroid hormone receptor superfamily are covered to provide a current view of how this class of receptors stabilizes transcription initiation complexes.

Original languageEnglish (US)
Pages (from-to)531-541
Number of pages11
JournalClinics in Laboratory Medicine
Volume13
Issue number3
DOIs
StatePublished - 1993

ASJC Scopus subject areas

  • Clinical Biochemistry
  • Biochemistry, medical

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