TY - JOUR
T1 - Molecular mechanisms of increased intrahepatic resistance in portal hypertension
AU - Shah, Vijay
PY - 2007/11
Y1 - 2007/11
N2 - Portal hypertension is associated with changes in the intrahepatic, systemic, and portosystemic collateral circulation. Alterations in vasoreactivity (vasodilation and vasoconstriction) play a central role in the pathogenesis of portal hypertension by contributing to increased intrahepatic resistance, hyperdynamic circulation, and expansion of the collateral circulation. Portal hypertension is also importantly characterized by changes in vascular structure; termed vascular remodeling, which is an adaptive response of the vessel wall that occurs in response to chronic changes in the environment such as shear stress. These complementary processes of vasoreactivity and vascular remodeling contribute importantly to increased intrahepatic resistance and represent important targets in the treatment of portal hypertension. This review will focus on these processes within the intrahepatic circulation, a circulatory bed whose study, that Dr Roberto Groszmann has pioneered.
AB - Portal hypertension is associated with changes in the intrahepatic, systemic, and portosystemic collateral circulation. Alterations in vasoreactivity (vasodilation and vasoconstriction) play a central role in the pathogenesis of portal hypertension by contributing to increased intrahepatic resistance, hyperdynamic circulation, and expansion of the collateral circulation. Portal hypertension is also importantly characterized by changes in vascular structure; termed vascular remodeling, which is an adaptive response of the vessel wall that occurs in response to chronic changes in the environment such as shear stress. These complementary processes of vasoreactivity and vascular remodeling contribute importantly to increased intrahepatic resistance and represent important targets in the treatment of portal hypertension. This review will focus on these processes within the intrahepatic circulation, a circulatory bed whose study, that Dr Roberto Groszmann has pioneered.
KW - Angiogenesis
KW - Nitric oxide
KW - Portal hypertension
KW - Vasoregulation
UR - http://www.scopus.com/inward/record.url?scp=35848965448&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=35848965448&partnerID=8YFLogxK
U2 - 10.1097/MCG.0b013e318150d0e1
DO - 10.1097/MCG.0b013e318150d0e1
M3 - Article
C2 - 17975474
AN - SCOPUS:35848965448
SN - 0192-0790
VL - 41
SP - S259-S261
JO - Journal of clinical gastroenterology
JF - Journal of clinical gastroenterology
IS - SUPPL. 3
ER -