Molecular mechanisms of Cryptosporidium-induced host actin cytoskeleton dynamics

Steven P. O'hara, Xian Ming Chen, Nicholas F La Russo

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Early ultrastructural observations of Cryptosporidium parvum-infected cells consistentlydescribed the accumulation of microfilaments beneath the dense band, suggesting theinitiation of actin reorganization within the host cell. Immunolocalization and forcedexpression of β-actin green fluorescent protein confirmed the rearrangement of hostactin filaments, and recruitment of actin-binding proteins to infection sites. Subsequentstudies have demonstrated the importance of host signalling cascades leading to actinreorganization during early invasion events. Therefore, this chapter focuses on actin reorganizationduring sporozoite internalization and development, concentrating primarilyon the molecular mechanisms of actin reorganization.

Original languageEnglish (US)
Title of host publicationGiardia and Cryptosporidium: From Molecules to Diseases
PublisherCABI Publishing
Pages418-427
Number of pages10
ISBN (Print)9781845933913
StatePublished - Feb 25 2009

Fingerprint

Cryptosporidium
microfilaments
Actin Cytoskeleton
actin
Actins
microfilament proteins
Cryptosporidium parvum
Microfilament Proteins
Sporozoites
sporozoites
concentrating
Green Fluorescent Proteins
green fluorescent protein
cells
Infection
infection

ASJC Scopus subject areas

  • veterinary(all)
  • Agricultural and Biological Sciences(all)

Cite this

O'hara, S. P., Chen, X. M., & La Russo, N. F. (2009). Molecular mechanisms of Cryptosporidium-induced host actin cytoskeleton dynamics. In Giardia and Cryptosporidium: From Molecules to Diseases (pp. 418-427). CABI Publishing.

Molecular mechanisms of Cryptosporidium-induced host actin cytoskeleton dynamics. / O'hara, Steven P.; Chen, Xian Ming; La Russo, Nicholas F.

Giardia and Cryptosporidium: From Molecules to Diseases. CABI Publishing, 2009. p. 418-427.

Research output: Chapter in Book/Report/Conference proceedingChapter

O'hara, SP, Chen, XM & La Russo, NF 2009, Molecular mechanisms of Cryptosporidium-induced host actin cytoskeleton dynamics. in Giardia and Cryptosporidium: From Molecules to Diseases. CABI Publishing, pp. 418-427.
O'hara SP, Chen XM, La Russo NF. Molecular mechanisms of Cryptosporidium-induced host actin cytoskeleton dynamics. In Giardia and Cryptosporidium: From Molecules to Diseases. CABI Publishing. 2009. p. 418-427
O'hara, Steven P. ; Chen, Xian Ming ; La Russo, Nicholas F. / Molecular mechanisms of Cryptosporidium-induced host actin cytoskeleton dynamics. Giardia and Cryptosporidium: From Molecules to Diseases. CABI Publishing, 2009. pp. 418-427
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