Molecular mechanism of ATP-dependent solute transport by multidrug resistance-associated protein 1.

Xiu bao Chang

Research output: Contribution to journalReview article

24 Scopus citations

Abstract

Millions of new cancer patients are diagnosed each year and over half of these patients die from this devastating disease. Thus, cancer causes a major public health problem worldwide. Chemotherapy remains the principal mode to treat many metastatic cancers. However, occurrence of cellular multidrug resistance (MDR) prevents efficient killing of cancer cells, leading to chemotherapeutic treatment failure. Over-expression of ATP-binding cassette transporters, such as P-glycoprotein, breast cancer resistance protein and/or multidrug resistance-associated protein 1 (MRP1), confers an acquired MDR due to their capabilities of transporting a broad range of chemically diverse anticancer drugs across the cell membrane barrier. In this review, the molecular mechanism of ATP-dependent solute transport by MRP1 will be addressed.

Original languageEnglish (US)
Pages (from-to)223-249
Number of pages27
JournalMethods in molecular biology (Clifton, N.J.)
Volume596
StatePublished - 2010

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ASJC Scopus subject areas

  • Molecular Biology
  • Genetics

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