Molecular malfeasance mediating myeloid malignancies: The genetics of acute myeloid leukemia

Rebecca L. King, Adam Bagg

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Scopus citations

Abstract

A remarkable number of different, but recurrent, structural cytogenetic abnormalities have been observed in AML, and the 2016 WHO AML classification system incorporates numerous distinct entities associated with translocations or inversions, as well as others associated with single gene mutations into a category entitled “AML with recurrent genetic abnormalities.” The AML classification is heavily reliant on cytogenetic and molecular information based on conventional genetic techniques (including karyotype, fluorescence in situ hybridization, reverse transcriptase polymerase chain reaction, single gene sequencing), but large-scale next generation sequencing is now identifying novel mutations. With targeted next generation sequencing panels now clinically available at many centers, detection of mutations, as well as alterations in epigenetic modifiers, is becoming part of the routine diagnostic evaluation of AML and will likely impact future classification schemes.

Original languageEnglish (US)
Title of host publicationMethods in Molecular Biology
PublisherHumana Press Inc.
Pages1-17
Number of pages17
DOIs
StatePublished - Jan 1 2017

Publication series

NameMethods in Molecular Biology
Volume1633
ISSN (Print)1064-3745

Keywords

  • 2016 WHO AML classification
  • Acute myeloid leukemia
  • Acute promyelocytic leukemia
  • Epigenetics
  • FISH
  • Karyotype
  • NGS
  • RT-PCR

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics

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  • Cite this

    King, R. L., & Bagg, A. (2017). Molecular malfeasance mediating myeloid malignancies: The genetics of acute myeloid leukemia. In Methods in Molecular Biology (pp. 1-17). (Methods in Molecular Biology; Vol. 1633). Humana Press Inc.. https://doi.org/10.1007/978-1-4939-7142-8_1